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yjgF putative translation initiation inhibitor [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1255984, updated on 6-Jun-2024

Summary

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Gene symbol
yjgF
Gene description
putative translation initiation inhibitor
Locus tag
STM4458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (4703051..4703448, complement)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene P-type ATPase Neighboring gene putative transposase Neighboring gene aspartate carbamoyltransferase, regulatory subunit Neighboring gene aspartate carbamoyltransferase, catalytic subunit Neighboring gene pyrBI operon leader peptide Neighboring gene putative cytoplasmic protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase. Flynn JM, et al. Mol Microbiol, 2013 Aug. PMID 23815688, Free PMC Article
  2. RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life. Lambrecht JA, et al. mBio, 2013 Feb 5. PMID 23386433, Free PMC Article
  3. YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. Christopherson MR, et al. J Bacteriol, 2008 Apr. PMID 18296521, Free PMC Article
  4. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotypically, strains of Salmonella enterica that lack RidA accumulated significantly more pyruvate in the growth medium than wild-type strains.
    Title: Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase.
  2. Here authors demonstrate the damaging potential of enamines in the absence of RidA (formerly known as YjgF) proteins.
    Title: RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life.
  3. Study concludes that the isoleucine requirement of a yjgF mutant on pyruvate is a consequence of the decreased transaminase B (IlvE) activity.
    Title: YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium.
Submit: New GeneRIF Correction

General gene information

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regulatory

  • Loc: c4703448-4703443 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
putative translation initiation inhibitor
NP_463318.1
  • similar to E. coli orf, hypothetical protein (AAC77200.1); Blastp hit to AAC77200.1 (141 aa), 93% identity in aa 14 - 141

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    4703051..4703448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_463318.1 putative translation initiation inhibitor [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_463318.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5H7CWJ3, A0A5U1JDV2, A0A5Y4TML9, A0A739DSS2, A0A744GSQ3, A0A748A5T0
    Conserved Domains (1) summary
    cl10015
    Location:1 → 127
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7CP78.1

Gene LinkOut

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