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melB GPH family melibiose permease II [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1255825, updated on 6-Oct-2023

Summary

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Gene symbol
melB
Gene description
GPH family melibiose permease II
Locus tag
STM4299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (4543843..4545283)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene regulator of melibiose operon Neighboring gene alpha-galactosidase Neighboring gene fumarase B Neighboring gene Dcu family anaerobic C4-dicarboxylate transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB. Guan L, et al. Commun Biol, 2021 Aug 2. PMID 34341464, Free PMC Article
  2. Structure-based mechanism for Na(+)/melibiose symport by MelB. Ethayathulla AS, et al. Nat Commun, 2014. PMID 24389923, Free PMC Article
  3. Insights into the inhibitory mechanisms of the regulatory protein IIA(Glc) on melibiose permease activity. Hariharan P, et al. J Biol Chem, 2014 Nov 21. PMID 25296751, Free PMC Article
  4. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB.
    Title: X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB.
  2. 3D crystal structures of MelB in two conformations are presented, representing an outward partially occluded and an outward inactive state of MelB. Three conserved acidic residues form a pyramidal-shaped cation-binding site for Na+, Li+ or H+.
    Title: Structure-based mechanism for Na(+)/melibiose symport by MelB.
  3. Data show that the regulatory protein IIA(Glc) directly binds to melibiose permease (MelB) with dissociation constant values 3-10 muM.
    Title: Insights into the inhibitory mechanisms of the regulatory protein IIA(Glc) on melibiose permease activity.
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General gene information

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regulatory

  • Loc: 4543843-4543848 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
GPH family melibiose permease II
NP_463164.1
  • melibiose carrier protein (thiomethylgalactoside permease)(melibiose permease) (Na+ (Li+)/melibiose symporter) (melibiosetransporter). (SW:MELB_SALTY)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    4543843..4545283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_463164.1 GPH family melibiose permease II [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_463164.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A701AYW1, A0A761TGW5
    Conserved Domains (1) summary
    PRK10429
    Location:1 → 476
    PRK10429; melibiose:sodium transporter MelB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30878.3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases