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LOC125387324 Sharpr-MPRA regulatory region 7824 [ Homo sapiens (human) ]

Gene ID: 125387324, updated on 10-Oct-2023

Summary

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Gene symbol
LOC125387324
Gene description
Sharpr-MPRA regulatory region 7824
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 24:Quies, heterochromatin/dead zone). [provided by RefSeq, May 2022]
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Genomic context

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Location:
21p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (10731794..10732088)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10855487-10856405 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10854560-10855064 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10853405-10854344 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10846505-10847020 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10842671-10843548 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10838130-10838637 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10837621-10838129 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10836528-10837187 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10835867-10836527 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10833885-10834544 Neighboring gene immunoglobulin heavy variable 1/OR21-1 (non-functional) Neighboring gene solute carrier family 25 member 15 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr21:10828675-10829607 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10833223-10833884 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10809989-10810538 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10806976-10807936 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10806014-10806975 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10805267-10805830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10804701-10805266 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10798959-10799488 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10794218-10794859 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10791113-10792056 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10792057-10792998 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chr21:10793041-10793561 and GRCh37_chr21:10793562-10794081 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10795186-10795980 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10795981-10796775 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10790482-10791066 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10789628-10790471 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10788693-10789551 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10785765-10786616 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10764761-10765275 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10765790-10766304 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10765276-10765789 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10760631-10761606 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10759655-10760630 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10750231-10750944 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10749518-10750230 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10748804-10749517 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10743796-10744614 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10742976-10743795 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10733773-10734290 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:10732737-10733254 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr21:10732217-10732736 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10722404-10722926 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10721881-10722403 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10722927-10723449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10725560-10726366 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10726367-10727171 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10727172-10727977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10723450-10723973 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10715601-10716123 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10715077-10715600 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10716124-10716646 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10716647-10717169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10717694-10718216 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10718741-10719263 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10719264-10719787 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10721357-10721880 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10705779-10706632 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10699388-10700124 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:10698652-10699387 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:10697915-10698651 Neighboring gene OCT4 hESC enhancer GRCh37_chr21:14353861-14354362 Neighboring gene ankyrin repeat domain 30B pseudogene 2 Neighboring gene RNA, U6 small nuclear 614, pseudogene Neighboring gene vomeronasal 1 receptor 109 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081061.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    10731794..10732088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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