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sopB Pathogenicity island encoded protein: SPI5 [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1252609, updated on 10-Oct-2024

Summary

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Gene symbol
sopB
Gene description
Pathogenicity island encoded protein: SPI5
Locus tag
STM1091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
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Genomic context

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Sequence:
NC_003197.2 (1178219..1179912, complement)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene Pathogenicity island encoded protein: SPI5 Neighboring gene Pathogenicity island encoded protein: SPI5 Neighboring gene Pathogenicity island encoded protein: SPI5 Neighboring gene Pathogenicity island encoded protein: SPI5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deceiving the big eaters: Salmonella Typhimurium SopB subverts host cell xenophagy in macrophages via dual mechanisms. Chatterjee R, et al. Microbes Infect, 2023 Jul-Aug. PMID 37019426
  2. Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry. Piscatelli HL, et al. Cell Microbiol, 2016 May. PMID 26537021
  3. Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive. Cooper KG, et al. PLoS One, 2011. PMID 21779406, Free PMC Article
  4. Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system. Kim Y, et al. Eukaryot Cell, 2011 Jun. PMID 21498643, Free PMC Article
  5. The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Bakowski MA, et al. Cell Host Microbe, 2010 Jun 25. PMID 20542249

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deceiving the big eaters: Salmonella Typhimurium SopB subverts host cell xenophagy in macrophages via dual mechanisms.
    Title: Deceiving the big eaters: Salmonella Typhimurium SopB subverts host cell xenophagy in macrophages via dual mechanisms.
  2. These findings show that SopB suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial reactive oxygen species generation.
    Title: The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recruitment to mitochondria.
  3. This work reveals the unique ability of bacterial effector protein SopB to utilize both its 4- and 5-phosphatase activities to regulate phosphoinositide dynamics to promote bacterial entry
    Title: Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry.
  4. SopB secretion was also considerably impaired in the absence of dam.
    Title: Dam methylation regulates the expression of SPI-5-encoded sopB gene in Salmonella enterica serovar Typhimurium.
  5. The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners
    Title: The structural organization of the N-terminus domain of SopB, a virulence factor of Salmonella, depends on the nature of its protein partners.
  6. Data found that SopB-dependent membrane translocation and phosphorylation of Akt are insensitive to the PI3K inhibitor wortmannin.
    Title: Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive.
  7. Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system
    Title: Killing of Candida albicans filaments by Salmonella enterica serovar Typhimurium is mediated by sopB effectors, parts of a type III secretion system.
  8. SopB may play a role in protecting mice from Salmonella colonization through activation of Akt2
    Title: Protective role of Akt2 in Salmonella enterica serovar typhimurium-induced gastroenterocolitis.
  9. SopB activity results in dissociation of a number of host-cell endocytic trafficking proteins from this compartment and inhibits Salmonella-containing vacuole-lysosome fusion.
    Title: The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole.
  10. These data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization.
    Title: Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane.
Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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regulatory

  • Loc: c1179912-1179907 regulatory_class = ribosome_binding_site

General protein information

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Preferred Names
Pathogenicity island encoded protein: SPI5
NP_460064.1
  • invasion gene D protein (gi|2582385)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    1178219..1179912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_460064.1 Pathogenicity island encoded protein: SPI5 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_460064.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5X6BSW7, A0A5Y2FKY4, A0A602C651, A0A603MDS7, A0A623T1X2, A0A708VX67, A0A709DD30, A0A711UF74, A0A711YHD2, A0A713Q750, A0A732K0Q1, A0A733XTL3, A0A743SJC9, A0A757JXW0
    Conserved Domains (1) summary
    pfam05925
    Location:1 → 559
    IpgD; Enterobacterial virulence protein IpgD
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O30916.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials