U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cobC alpha ribazole-5'-P phosphatase in cobalamin synthesis [ Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ]

Gene ID: 1252163, updated on 6-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
cobC
Gene description
alpha ribazole-5'-P phosphatase in cobalamin synthesis
Locus tag
STM0643
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 (strain: LT2, serovar: Typhimurium, sub-species: enterica, culture-collection: ATCC:700720, culture-collection: SGSC:1412, type-material: type strain of Salmonella enterica)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_003197.2 (705075..705693, complement)

NC_003197.2Genomic Context describing neighboring genes Neighboring gene rod shape-determining membrane protein; cell elongation in e phase Neighboring gene cell elongation specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase) Neighboring gene putative cytoplasmic protein Neighboring gene putative ACR, homolog of plant Iojap protein Neighboring gene putative aminotransferase in cobalamin synthesis Neighboring gene putative nicotinic acid mononucleotide adenylyltransferase Neighboring gene DNA polymerase III, delta subunit Neighboring gene a minor lipoprotein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003197.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway. Zayas CL, et al. J Bacteriol, 2007 Mar. PMID 17209023, Free PMC Article
  2. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. McClelland M, et al. Nature, 2001 Oct 25. PMID 11677609

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. based on the data reported herein, we conclude that removal of the phosphoryl group from AdoCbl-5'-P is the last step in adenosylcobalamin-5'-phosphate (AdoCbl) biosynthesis and that the reaction is catalyzed by the AdoCbl-5'-P phosphatase (CobC) enzyme.
    Title: Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

regulatory

  • Loc: c705693-705688 regulatory_class = ribosome_binding_site

General protein information

Go to the top of the page Help
Preferred Names
alpha ribazole-5'-P phosphatase in cobalamin synthesis
NP_459635.1
  • alpha-ribazole-5'-phosphate phosphatase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003197.2 Reference assembly

    Range
    705075..705693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_459635.1 alpha ribazole-5'-P phosphatase in cobalamin synthesis [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]

    See identical proteins and their annotated locations for NP_459635.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6Y2T9V1
    Conserved Domains (1) summary
    PRK15004
    Location:1 → 199
    PRK15004; adenosylcobalamin/alpha-ribazole phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39701.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.