U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC125146423 Sharpr-MPRA regulatory region 8054 [ Homo sapiens (human) ]

Gene ID: 125146423, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC125146423
Gene description
Sharpr-MPRA regulatory region 8054
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive DNase unmatched - State 4:PromP, inactive/poised promoter, highly conserved). [provided by RefSeq, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (19885107..19885401)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19815877..19816171)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing K Neighboring gene uncharacterized LOC105371115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:19778410-19778910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:19778911-19779411 Neighboring gene LARP7 pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19864519-19865437 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19865438-19866357 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:19869508-19870707 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19871981-19872562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19873143-19873723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19879518-19880020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:19883504-19884004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19887125-19887940 Neighboring gene G protein-coupled receptor class C group 5 member B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19890529-19891258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19891259-19891990 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:19891991-19892720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:19892721-19893452 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:19893453-19894182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:19894183-19894913 Neighboring gene uncharacterized LOC105371116 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:19980466-19980966 Neighboring gene uncharacterized LOC105371117 Neighboring gene uncharacterized LOC124903660

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_080348.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    19885107..19885401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    19815877..19816171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases