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SNHG29 small nucleolar RNA host gene 29 [ Homo sapiens (human) ]

Gene ID: 125144, updated on 12-Feb-2024

Summary

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Official Symbol
SNHG29provided by HGNC
Official Full Name
small nucleolar RNA host gene 29provided by HGNC
Primary source
HGNC:HGNC:28619
See related
Ensembl:ENSG00000175061 AllianceGenome:HGNC:28619
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSAP19; C17orf45; NCRNA00188; FAM211A-AS1; LRRC75A-AS1; C17orf76-AS1
Expression
Ubiquitous expression in bone marrow (RPKM 110.6), thyroid (RPKM 105.4) and 25 other tissues See more
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Genomic context

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Location:
17p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16438987..16470648)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (16341290..16372939)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16342301..16373962)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16329088-16329588 Neighboring gene transient receptor potential cation channel subfamily V member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16339567-16340199 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16340803-16341704 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16341705-16342604 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16342605-16343506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16347109-16348008 Neighboring gene small nucleolar RNA, C/D box 49B Neighboring gene small nucleolar RNA, C/D box 49A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16351973-16352474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16352475-16352974 Neighboring gene small nucleolar RNA, C/D box 65 Neighboring gene leucine rich repeat containing 75A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16359695-16360196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16360197-16360696 Neighboring gene Sharpr-MPRA regulatory regions 7543 and 3494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16369025-16369816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16379787-16380698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16380699-16381609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16386369-16387185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16387442-16388368 Neighboring gene uncharacterized LOC124903936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16389294-16390219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16390220-16391144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:16400945-16401445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:16419598-16420797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11767 Neighboring gene uncharacterized LOC124903940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development. Liu S, et al. Leukemia, 2023 Jul. PMID 37157016
  2. LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma. Pang Q, et al. Cancer Biol Ther, 2020 Nov 1. PMID 33131397, Free PMC Article
  3. Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. Jiang J, et al. Placenta, 2021 Jan 1. PMID 33080448
  4. Long noncoding RNA LRRC75A-AS1 inhibits cell proliferation and migration in colorectal carcinoma. Chen J, et al. Exp Biol Med (Maywood), 2019 Oct. PMID 31505952, Free PMC Article
  5. A three‑lncRNA signature for prognosis prediction of acute myeloid leukemia in patients. Wang F, et al. Mol Med Rep, 2018 Aug. PMID 29901168, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway.
    Title: Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway.
  2. A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development.
    Title: A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development.
  3. LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.
    Title: LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.
  4. Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation.
    Title: Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation.
  5. Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
    Title: Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
  6. LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma.
    Title: LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma.
  7. Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC.
    Title: Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC.
  8. LRRC75A-AS1 might serve as an anti-oncogene for colorectal cancer tumorigenesis and advancement.
    Title: Long noncoding RNA LRRC75A-AS1 inhibits cell proliferation and migration in colorectal carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • C17orf76 antisense RNA 1 (non-protein coding)
  • FAM211A antisense RNA 1
  • LRRC75A antisense RNA 1

Clone Names

  • FLJ25777, MGC40157

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027158.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment and two exons, compared to variant 6.
    Source sequence(s)
    AC093484, CN297624
    Related
    ENST00000580180.6

  2. NR_027159.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, BC027986, CF126952
    Related
    ENST00000655540.1

  3. NR_027160.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, BC027986

  4. NR_027161.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, BC027986, BQ954204
    Related
    ENST00000581913.5

  5. NR_027162.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript.
    Source sequence(s)
    AC093484, AK307982

  6. NR_027163.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal segment in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, BU599615
    Related
    ENST00000660020.1

  7. NR_027164.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two internal segments in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, CB150672
    Related
    ENST00000667979.2

  8. NR_027165.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two internal segments in the 5' region and an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, BP870476
    Related
    ENST00000666215.2

  9. NR_027166.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an internal segment and an exon in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, CD050014
    Related
    ENST00000663781.2

  10. NR_027167.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks two internal segments in the 5' region and an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, AK309961
    Related
    ENST00000483140.7

  11. NR_027168.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks an internal segment in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, BU506593
    Related
    ENST00000487066.6

  12. NR_027169.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks an internal segment in the 5' region and an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, BP353162
    Related
    ENST00000654778.1

  13. NR_027170.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks two internal segments in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484
    Related
    ENST00000481898.6

  14. NR_027171.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
    Source sequence(s)
    AC093484, BC027986, DA494627, DA793334

  15. NR_027172.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
    Source sequence(s)
    AC127540, DA193585

  16. NR_027173.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
    Source sequence(s)
    AC093484, DA793334, DA857697

  17. NR_027174.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
    Source sequence(s)
    AC093484, DA793334, DA802938

  18. NR_027175.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
    Source sequence(s)
    AC093484, DA485648

  19. NR_027176.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) lacks an internal segment and an exon in the 5' region, lacks two exons in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
    Source sequence(s)
    AC093484, AK308482, DA793334

  20. NR_027177.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
    Source sequence(s)
    AC093484, DA383448, DA793334

  21. NR_027178.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has multiple alternate 3' exons, compared to variant 6.
    Source sequence(s)
    AC093484, DA131201, DA793334

  22. NR_027179.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23) lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, DA867958, DW409012

  23. NR_027667.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an internal segment in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, AK307982, BC027986
    Related
    ENST00000475953.6

  24. NR_045021.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24) lacks an internal segment and an exon in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, AK098643, CD389053
    Related
    ENST00000582911.6

  25. NR_045022.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) lacks two internal segments and has an alternate segment in the 5' region, compared to variant 6.
    Source sequence(s)
    AC093484, DA440445

  26. NR_045023.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26) lacks an internal segment and an exon in the 5' region, lacks an exon in the 3' region, and has an alternate 3' exon, compared to variant 6.
    Source sequence(s)
    AC093484, AC127540, DA769571

  27. NR_045024.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27) lacks an exon in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, DB258221
    Related
    ENST00000584141.5

  28. NR_045025.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28) lacks an internal segment and an exon in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, DA793334

  29. NR_045026.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) lacks an internal segment in the 5' region and lacks an exon and has an alternate segment in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, DA867958

  30. NR_045027.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) lacks an exon in the 5' region and an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, BU165462
    Related
    ENST00000470491.7

  31. NR_045028.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) lacks an internal segment in the 5' region and lacks an exon in the 3' region, compared to variant 6.
    Source sequence(s)
    AC093484, BI333700

  32. NR_045029.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32) lacks an internal segment and an exon in the 5' region and has an alternate segement, compared to variant 6.
    Source sequence(s)
    AC093484, BQ070126
    Related
    ENST00000477249.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    16438987..16470648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    16341290..16372939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152350.3: Suppressed sequence

    Description
    NM_152350.3: This RefSeq was permanently suppressed because the gene is not considered to be protein-coding.
Nucleotide Protein
Heading Accession and Version

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