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CD300LB CD300 molecule like family member b [ Homo sapiens (human) ]

Gene ID: 124599, updated on 3-Apr-2024

Summary

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Official Symbol
CD300LBprovided by HGNC
Official Full Name
CD300 molecule like family member bprovided by HGNC
Primary source
HGNC:HGNC:30811
See related
Ensembl:ENSG00000178789 MIM:610705; AllianceGenome:HGNC:30811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM7; CLM-7; IREM3; TREM5; CD300b; IREM-3; TREM-5; CMRF35-A2
Summary
CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in appendix (RPKM 4.4), bone marrow (RPKM 2.5) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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See CD300LB in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74521174..74531475, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75411699..75421996, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72517313..72527614, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72448210-72449201 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72449202-72450192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72450947-72451617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12706 Neighboring gene uncharacterized LOC124904056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12707 Neighboring gene CD300a molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12710 Neighboring gene uncharacterized LOC107985074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72535116-72535616 Neighboring gene CD300c molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72546952-72547452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72547453-72547953 Neighboring gene CD300H molecule (gene/pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock. Voss OH, et al. Immunity, 2016 Jun 21. PMID 27261276, Free PMC Article
  2. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. Martínez-Barriocanal A, et al. J Immunol, 2006 Sep 1. PMID 16920917
  3. CD300 molecule regulation of human dendritic cell functions. Gasiorowski RE, et al. Immunol Lett, 2013 Jan. PMID 23072861
  4. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. Comas-Casellas E, et al. J Biol Chem, 2012 Mar 23. PMID 22291008, Free PMC Article
  5. Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Yamanishi Y, et al. Blood, 2008 Jan 15. PMID 17928527

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this paper identified CD300b as an lipopolysaccharide-recognizing receptor that regulated TLR4 signaling
    Title: Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.
  2. CD300LB expression is significantly upregulated in human masticatory mucosa during wound healing
    Title: Human gingiva transcriptome during wound healing.
  3. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
    Title: CD300 molecule regulation of human dendritic cell functions.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  6. although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells.
    Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.
  7. CD300b defines a nonclassical Ig receptor able to trigger signals by coupling distinct mediators and thus initiating different signaling pathways
    Title: Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
CMRF35-like molecule 7
Names
CD300 antigen like family member B
immune receptor expressed on myeloid cells 3
leukocyte mono-Ig-like receptor 5
triggering receptor expressed on myeloid cells 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174892.4 → NP_777552.3  CMRF35-like molecule 7 precursor

    See identical proteins and their annotated locations for NP_777552.3

    Status: VALIDATED

    Source sequence(s)
    AC079325, AK290925, BC028091
    Consensus CDS
    CCDS11700.2
    UniProtKB/Swiss-Prot
    A8K4G0, Q1EG73, Q8IX40, Q8N6D1
    Related
    ENSP00000376397.2, ENST00000392621.6
    Conserved Domains (2) summary
    cd05716
    Location:24 → 121
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:21 → 121
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74521174..74531475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257027.4 → XP_005257084.1  CMRF35-like molecule 7 isoform X1

    UniProtKB/TrEMBL
    B4DQ71
    Conserved Domains (2) summary
    cd05716
    Location:61 → 158
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:58 → 158
    IG_like; Immunoglobulin like

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791806.1 Reference GRCh38.p14 PATCHES

    Range
    97622..107923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333230.1 → XP_054189205.1  CMRF35-like molecule 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75411699..75421996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314994.1 → XP_054170969.1  CMRF35-like molecule 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8K4G0.2 GenPept UniProtKB/Swiss-Prot:A8K4G0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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