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MSI2 musashi RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 124540, updated on 3-Apr-2024

Summary

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Official Symbol
MSI2provided by HGNC
Official Full Name
musashi RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:18585
See related
Ensembl:ENSG00000153944 MIM:607897; AllianceGenome:HGNC:18585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSI2H
Summary
This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in adrenal (RPKM 11.7), ovary (RPKM 7.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (57255851..57701581)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58130926..58574836)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55333212..55762050)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:55156412-55157150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55163183-55163685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55168773-55169322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55170245-55170744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55186230-55186831 Neighboring gene Sharpr-MPRA regulatory region 9462 Neighboring gene AKAP1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55213025-55213556 Neighboring gene MPRA-validated peak2909 silencer Neighboring gene A-kinase anchoring protein 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:55273397-55274596 Neighboring gene uncharacterized LOC101927510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12427 Neighboring gene NANOG hESC enhancer GRCh37_chr17:55337123-55337646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12428 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55365995-55366170 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55415927-55416094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12430 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55441475-55441718 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55456920-55457574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55478625-55479135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55488073-55488574 Neighboring gene MPRA-validated peak2912 silencer Neighboring gene Sharpr-MPRA regulatory region 14735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12434 Neighboring gene Sharpr-MPRA regulatory region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12439 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55548443-55549306 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55549307-55550170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55562836-55563732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55573395-55573896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55584063-55584590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55588381-55588975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55588976-55589569 Neighboring gene uncharacterized LOC101927557 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:55601094-55602293 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:55605169-55606001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12442 Neighboring gene uncharacterized LOC107984993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12443 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55638731-55639231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55656316-55656816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55656817-55657317 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:55665351-55665880 Neighboring gene uncharacterized LOC101927539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55680421-55680920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55682575-55683470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12444 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55685282-55685876 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55685877-55686469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55716402-55717204 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55720638-55720787 Neighboring gene RNA, 7SL, cytoplasmic 449, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55726383-55727192 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55740323-55740615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55741794-55742400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55753573-55754072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55785092-55785592 Neighboring gene RNA, U7 small nuclear 134 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55804275-55804774 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55805921-55806176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12446 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:55813992-55814170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55828159-55828658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55838959-55839579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55839580-55840199 Neighboring gene MPRA-validated peak2914 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8751 Neighboring gene coiled-coil domain containing 182 Neighboring gene RN7SK pseudogene 94

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis. Wu W, et al. Medicine (Baltimore), 2022 Dec 30. PMID 36596017, Free PMC Article
  2. MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways. Veronez LC, et al. J Cell Biochem, 2021 Dec. PMID 34581457
  3. Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. Kharin L, et al. PLoS One, 2021. PMID 34237057, Free PMC Article
  4. MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma. Yiming R, et al. Cancer Sci, 2021 Sep. PMID 34145929, Free PMC Article
  5. Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target. Palacios F, et al. Leukemia, 2021 Apr. PMID 33504942, Free PMC Article

See all (149) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.
    Title: Musashi-2 potentiates colorectal cancer immune infiltration by regulating the post-translational modifications of HMGB1 to promote DCs maturation and migration.
  2. Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.
    Title: Clonal evolution dissection reveals that a high MSI2 level promotes chemoresistance in T-cell acute lymphoblastic leukemia.
  3. Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
    Title: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
  4. The TGF-beta/Smad2/3 signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.
    Title: The TGF-β/Smad(2/3) signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.
  5. Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.
    Title: Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.
  6. Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.
    Title: Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the musashi RNA-binding protein 2/oestrogen receptor alpha 1 axis.
  7. TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
    Title: TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
  8. Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
    Title: Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
  9. MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.
    Title: MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways.
  10. Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
    Title: Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3245, FLJ36569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 2
Names
musashi homolog 2
musashi-2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322250.2 → NP_001309179.1  RNA-binding protein Musashi homolog 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC005325, AI416968, AK295060
    Consensus CDS
    CCDS82168.1
    UniProtKB/TrEMBL
    A0A6Q8PF05, B4DHE8
    Related
    ENSP00000414671.2, ENST00000416426.6
    Conserved Domains (3) summary
    TIGR01628
    Location:13 → 321
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:89 → 162
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cl17169
    Location:1 → 87
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001322251.2 → NP_001309180.1  RNA-binding protein Musashi homolog 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC007431, AC015883, AC091181
    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  3. NM_138962.4 → NP_620412.1  RNA-binding protein Musashi homolog 2 isoform a

    See identical proteins and their annotated locations for NP_620412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, and encodes the longer isoform (a).
    Source sequence(s)
    AC005325, AC015883, AC091181, AI416968, BC001526
    Consensus CDS
    CCDS11596.1
    UniProtKB/Swiss-Prot
    Q7Z6M7, Q8N9T4, Q96DH6
    UniProtKB/TrEMBL
    A0A6Q8PF05
    Related
    ENSP00000284073.2, ENST00000284073.7
    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  4. NM_170721.2 → NP_733839.1  RNA-binding protein Musashi homolog 2 isoform b

    See identical proteins and their annotated locations for NP_733839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and coding region, compared to variant 1. The resulting isoform (b) contains distinct N- and C-termini compared to isoform a.
    Source sequence(s)
    AC007431, AC015883, AC091181
    Consensus CDS
    CCDS11597.1
    UniProtKB/Swiss-Prot
    Q96DH6
    Related
    ENSP00000313616.3, ENST00000322684.7
    Conserved Domains (2) summary
    cd12323
    Location:107 → 180
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:18 → 93
    RRM1_MSI2; RNA recognition motif 1 in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    57255851..57701581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435313.1 → XP_047291269.1  RNA-binding protein Musashi homolog 2 isoform X5

  2. XM_047435314.1 → XP_047291270.1  RNA-binding protein Musashi homolog 2 isoform X5

  3. XM_005257015.4 → XP_005257072.1  RNA-binding protein Musashi homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005257072.1

    UniProtKB/TrEMBL
    A0A6Q8PF05
    Conserved Domains (2) summary
    cd12323
    Location:111 → 184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17 → 109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

  4. XM_047435311.1 → XP_047291267.1  RNA-binding protein Musashi homolog 2 isoform X2

  5. XM_047435312.1 → XP_047291268.1  RNA-binding protein Musashi homolog 2 isoform X3

  6. XM_017024148.2 → XP_016879637.1  RNA-binding protein Musashi homolog 2 isoform X4

  7. XM_047435315.1 → XP_047291271.1  RNA-binding protein Musashi homolog 2 isoform X6

  8. XM_047435316.1 → XP_047291272.1  RNA-binding protein Musashi homolog 2 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    58130926..58574836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314985.1 → XP_054170960.1  RNA-binding protein Musashi homolog 2 isoform X5

  2. XM_054314986.1 → XP_054170961.1  RNA-binding protein Musashi homolog 2 isoform X5

  3. XM_054314981.1 → XP_054170956.1  RNA-binding protein Musashi homolog 2 isoform X1

  4. XM_054314982.1 → XP_054170957.1  RNA-binding protein Musashi homolog 2 isoform X2

  5. XM_054314983.1 → XP_054170958.1  RNA-binding protein Musashi homolog 2 isoform X3

  6. XM_054314984.1 → XP_054170959.1  RNA-binding protein Musashi homolog 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DH6.1 GenPept UniProtKB/Swiss-Prot:Q96DH6

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