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KRBOX5 KRAB box domain containing 5 [ Homo sapiens (human) ]

Gene ID: 124411, updated on 5-Mar-2024

Summary

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Official Symbol
KRBOX5provided by HGNC
Official Full Name
KRAB box domain containing 5provided by HGNC
Primary source
HGNC:HGNC:26987
See related
Ensembl:ENSG00000197302 AllianceGenome:HGNC:26987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF720
Summary
Predicted to be involved in regulation of transcription, DNA-templated. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 2.3), brain (RPKM 2.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
16p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31713244..31761565)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (32100634..32148944)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31724565..31772886)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 22 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31719202-31719702 Neighboring gene clustered mitochondria homolog pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10768 Neighboring gene uncharacterized LOC107983990 Neighboring gene vomeronasal 1 receptor 67 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lineage-specific transcription factors and the evolution of gene regulatory networks. Nowick K, et al. Brief Funct Genomics, 2010 Jan. PMID 20081217, Free PMC Article
  2. Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Hamilton AT, et al. Genome Res, 2006 May. PMID 16606703, Free PMC Article
  3. Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z. Chen Z, et al. J Biol Chem, 2021 Oct. PMID 34537242, Free PMC Article
  4. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 720 (ZNF720) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9313, MGC62019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
KRAB domain-containing protein 5
Names
putative protein ZNF720
zinc finger protein 720

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130913.2 → NP_001124385.1  KRAB domain-containing protein 5 isoform 9

    See identical proteins and their annotated locations for NP_001124385.1

    Status: VALIDATED

    Source sequence(s)
    AC074050, BC018134
    Consensus CDS
    CCDS45473.1
    UniProtKB/Swiss-Prot
    Q6ZQX1, Q7Z2F6
    Related
    ENSP00000319222.9, ENST00000316491.14
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  2. NM_001394173.1 → NP_001381102.1  KRAB domain-containing protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:231 → 539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001394174.1 → NP_001381103.1  KRAB domain-containing protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Consensus CDS
    CCDS92144.1
    UniProtKB/TrEMBL
    E9PMU6
    Related
    ENSP00000437310.2, ENST00000529515.2
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:229 → 537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236 → 256
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001394175.1 → NP_001381104.1  KRAB domain-containing protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (3) summary
    COG5048
    Location:197 → 505
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:204 → 224
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. NM_001394176.1 → NP_001381105.1  KRAB domain-containing protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (2) summary
    COG5048
    Location:175 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001394177.1 → NP_001381106.1  KRAB domain-containing protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (2) summary
    COG5048
    Location:163 → 471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001394178.1 → NP_001381107.1  KRAB domain-containing protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (2) summary
    COG5048
    Location:163 → 471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001394179.1 → NP_001381108.1  KRAB domain-containing protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (2) summary
    COG5048
    Location:163 → 471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001394180.1 → NP_001381109.1  KRAB domain-containing protein 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (2) summary
    COG5048
    Location:163 → 471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001394181.1 → NP_001381110.1  KRAB domain-containing protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (1) summary
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  11. NM_001394182.1 → NP_001381111.1  KRAB domain-containing protein 5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (1) summary
    smart00349
    Location:4 → 44
    KRAB; krueppel associated box

  12. NM_001394183.1 → NP_001381112.1  KRAB domain-containing protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (1) summary
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  13. NM_001394184.1 → NP_001381113.1  KRAB domain-containing protein 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050

  14. NM_001394185.1 → NP_001381114.1  KRAB domain-containing protein 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Conserved Domains (1) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box

  15. NM_001394186.1 → NP_001381115.1  KRAB domain-containing protein 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050
    Consensus CDS
    CCDS92145.1
    UniProtKB/TrEMBL
    A0A8I5KY90
    Related
    ENSP00000509660.1, ENST00000689850.1
    Conserved Domains (1) summary
    cl02581
    Location:1 → 32
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RNA

  1. NR_172085.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050

  2. NR_172086.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC002519, AC074050

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31713244..31761565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433621.1 → XP_047289577.1  KRAB domain-containing protein 5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    32100634..32148944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379609.1 → XP_054235584.1  KRAB domain-containing protein 5 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004300.1: Suppressed sequence

    Description
    NM_001004300.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2F6.1 GenPept UniProtKB/Swiss-Prot:Q7Z2F6

Gene LinkOut

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