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LOC124292582 Sharpr-MPRA regulatory region 15656 [ Homo sapiens (human) ]

Gene ID: 124292582, updated on 10-Oct-2023

Summary

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Gene symbol
LOC124292582
Gene description
Sharpr-MPRA regulatory region 15656
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 22:ReprW, weaker Polycomb repression). This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
9q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (62838105..62838399)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (66493929..66494223)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 4 pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:47049006-47049525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:47049526-47050044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66455492-66456238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66456239-66456984 Neighboring gene uncharacterized LOC107987020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66457043-66457922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66457923-66458800 Neighboring gene long intergenic non-protein coding RNA 1410 Neighboring gene RNA, 5S ribosomal pseudogene 283 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:66464814-66465421 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:66470759-66471281 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:66478631-66479190 Neighboring gene PTGER4P2-CDK2AP2P2 readthrough, transcribed pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66486627-66487478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66489090-66489619 Neighboring gene uncharacterized LOC100132249 Neighboring gene MPRA-validated peak7249 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66500322-66500855 Neighboring gene cyclin dependent kinase 2 associated protein 2 pseudogene 2 Neighboring gene prostaglandin E receptor 4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  2. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 19924

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_078826.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    62838105..62838399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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