U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cbx5 chromobox 5 [ Mus musculus (house mouse) ]

Gene ID: 12419, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Cbx5provided by MGI
Official Full Name
chromobox 5provided by MGI
Primary source
MGI:MGI:109372
See related
Ensembl:ENSMUSG00000009575 AllianceGenome:MGI:109372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HP1; Hp1a; Hp1alpha; 2610029O15Rik
Summary
Enables several functions, including histone deacetylase binding activity; identical protein binding activity; and methylated histone binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in chromocenter; chromosomal region; and nucleolus. Part of histone deacetylase complex; histone methyltransferase complex; and transcription repressor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; nervous system; and sensory organ. Orthologous to human CBX5 (chromobox 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 47.5), whole brain E14.5 (RPKM 29.9) and 22 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cbx5 in Genome Data Viewer
Location:
15 F3; 15 58.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103099973..103148337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103191546..103239904, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Riken cDNA D930007P13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr15:102993642-102993943 Neighboring gene single-strand selective monofunctional uracil DNA glycosylase Neighboring gene STARR-seq mESC enhancer starr_39867 Neighboring gene STARR-seq mESC enhancer starr_39868 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene STARR-seq mESC enhancer starr_39872 Neighboring gene nuclear factor, erythroid derived 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. Muchardt C, et al. EMBO Rep, 2002 Oct. PMID 12231507, Free PMC Article
  2. HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. Panteleeva I, et al. EMBO J, 2007 Aug 8. PMID 17627279, Free PMC Article
  3. SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin. Maison C, et al. Nat Genet, 2011 Mar. PMID 21317888
  4. Interaction between HP1alpha and replication proteins in mammalian cells. Auth T, et al. Exp Cell Res, 2006 Oct 15. PMID 16950245
  5. Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Seki Y, et al. Dev Biol, 2005 Feb 15. PMID 15680362

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic target for HP1alpha-positive intrahepatic cholangiocarcinoma.
    Title: Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.
  2. HP1 maintains protein stability of H3K9 methyltransferases and demethylases.
    Title: HP1 maintains protein stability of H3K9 methyltransferases and demethylases.
  3. Cell adhesion molecule L1 interacts with the chromo shadow domain of heterochromatin protein 1 isoforms alpha, beta, and via its intracellular domain.
    Title: Cell adhesion molecule L1 interacts with the chromo shadow domain of heterochromatin protein 1 isoforms α, β, and ɣ via its intracellular domain.
  4. Targeting Cbx3/HP1gamma Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.
    Title: Targeting Cbx3/HP1γ Induces LEF-1 and IL-21R to Promote Tumor-Infiltrating CD8 T-Cell Persistence.
  5. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.
    Title: CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.
  6. Aurora kinase B S92-phosphorylated HP1alpha is generated in cells at early prophase, localizes to centromeres, and associates with regulators of chromosome stability
    Title: Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.
  7. We show here that the unstructured hinge domain, necessary for the targeting of HP1alpha to constitutive heterochromatin, recognizes parallel G-quadruplex (G4) assemblies formed by the TElomeric Repeat-containing RNA (TERRA) transcribed from the telomere.
    Title: Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes.
  8. results reveal that ADNP, via the recruitment of HP1 and CHD4, regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues
    Title: Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.
  9. HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.
    Title: Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells.
  10. demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin
    Title: Actin cytoskeleton differentially alters the dynamics of lamin A, HP1α and H2B core histone proteins to remodel chromatin condensation state in living cells.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
  
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in pericentric heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
chromobox protein homolog 5
Names
HP1 alpha
chromobox homolog 5
heterochromatin protein 1 alpha
heterochromatin protein 1 homolog alpha
mHP1(alpha)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076789.2 → NP_001070257.1  chromobox protein homolog 5

    See identical proteins and their annotated locations for NP_001070257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC162693, AC164069
    Consensus CDS
    CCDS37231.1
    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Related
    ENSMUSP00000113157.2, ENSMUST00000118152.8
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  2. NM_001110216.1 → NP_001103686.1  chromobox protein homolog 5

    See identical proteins and their annotated locations for NP_001103686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC162693, AC164069, AK030366, AK030442, BM247903
    Consensus CDS
    CCDS37231.1
    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Related
    ENSMUSP00000113158.2, ENSMUST00000122182.2
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  3. NM_001358950.1 → NP_001345879.1  chromobox protein homolog 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC162693, AC164069
    Consensus CDS
    CCDS37231.1
    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  4. NM_007626.3 → NP_031652.1  chromobox protein homolog 5

    See identical proteins and their annotated locations for NP_031652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2, 3 and 4.
    Source sequence(s)
    AC162693, AC164069
    Consensus CDS
    CCDS37231.1
    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Related
    ENSMUSP00000104441.4, ENSMUST00000108813.10
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103099973..103148337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520372.5 → XP_006520435.1  chromobox protein homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006520435.1

    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  2. XM_006520374.4 → XP_006520437.1  chromobox protein homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006520437.1

    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  3. XM_006520376.4 → XP_006520439.1  chromobox protein homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006520439.1

    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  4. XM_030248308.2 → XP_030104168.1  chromobox protein homolog 5 isoform X1

    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  5. XM_006520375.5 → XP_006520438.1  chromobox protein homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_006520438.1

    UniProtKB/Swiss-Prot
    Q61686, Q9CS35, Q9CXD1
    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cd18655
    Location:116 → 173
    CSD_HP1alpha_Cbx5; chromo shadow domain of heterochromatin protein 1 homolog alpha

  6. XM_006520377.3 → XP_006520440.1  chromobox protein homolog 5 isoform X2

    Conserved Domains (2) summary
    cd18651
    Location:19 → 68
    CD_HP1alpha_Cbx5; chromodomain of heterochromatin protein 1 homolog alpha
    cl28914
    Location:116 → 142
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61686.1 GenPept UniProtKB/Swiss-Prot:Q61686

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous