U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC124188222 Sharpr-MPRA regulatory region 2678 [ Homo sapiens (human) ]

Gene ID: 124188222, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC124188222
Gene description
Sharpr-MPRA regulatory region 2678
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 23:Low, low signal proximal to active elements). [provided by RefSeq, Feb 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC124188222 in Genome Data Viewer
Location:
8q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124668348..124668642)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125801399..125801693)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125680589..125680883)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375740 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27888 Neighboring gene uncharacterized LOC124902016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27889 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:125632749-125633948 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:125638519-125639718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27893 Neighboring gene Sharpr-MPRA regulatory region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27895 Neighboring gene Sharpr-MPRA regulatory region 8202 Neighboring gene uncharacterized LOC105375741 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:125764038-125764579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125810571-125811072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125811073-125811572 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_078631.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    124668348..124668642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    125801399..125801693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases