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Cbln2 cerebellin 2 precursor protein [ Mus musculus (house mouse) ]

Gene ID: 12405, updated on 28-Oct-2024

Summary

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Official Symbol
Cbln2provided by MGI
Official Full Name
cerebellin 2 precursor proteinprovided by MGI
Primary source
MGI:MGI:88282
See related
Ensembl:ENSMUSG00000024647 AllianceGenome:MGI:88282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730004O05; 6330593N19Rik
Summary
The protein encoded by this gene belongs to a family of secreted neuronal glycoproteins. The transcript is broadly expressed in the embryonic and adult brain with higher levels in some regions including the olfactory bulb, thalamus, and cerebral cortex. The protein can bind to presynaptic neurexins and induce synaptogenesis in cultured neurons. Null mutant mice are viable, fertile and do not display obvious neuroanatomical defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in CNS E18 (RPKM 8.2), whole brain E14.5 (RPKM 7.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Cbln2 in Genome Data Viewer
Location:
18 E4; 18 58.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (86727226..86736410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (86711061..86718283)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25453 Neighboring gene predicted gene, 54041 Neighboring gene neuropilin (NRP) and tolloid (TLL)-like 1 Neighboring gene STARR-seq mESC enhancer starr_45283 Neighboring gene STARR-seq mESC enhancer starr_45284 Neighboring gene STARR-seq mESC enhancer starr_45285 Neighboring gene predicted gene, 46615 Neighboring gene DNA methyltransferase 1-associated protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Seigneur E, et al. Mol Psychiatry, 2021 Dec. PMID 34158618, Free PMC Article
  2. Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord. Cagle MC, et al. J Comp Neurol, 2014 Feb 1. PMID 23853053, Free PMC Article
  3. Transcriptomic encoding of sensorimotor transformation in the midbrain. Xie Z, et al. Elife, 2021 Jul 28. PMID 34318750, Free PMC Article
  4. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Seigneur E, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30287486, Free PMC Article
  5. Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. Yasumura M, et al. J Neurochem, 2012 Jun. PMID 22191730

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
    Title: Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
  2. Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors.
    Title: Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs.
  3. Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin 1beta (+S4) and postsynaptic GluD1.
    Title: Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.
  4. Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons.
    Title: Cerebellins are differentially expressed in selective subsets of neurons throughout the brain.
  5. that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord
    Title: Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
  6. GluRdelta1 stimulated inhibitory synapse formation in the presence of Cbln1 or Cbln2
    Title: Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes.
  7. These results suggest that Cbln1 and Cbln2 play a role in synapse formation of cortical neurons by interacting with NRXNs containing S4.
    Title: Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of synapse structure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of synapse structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spontaneous synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trans-synaptic signaling, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in trans-synaptic signaling, modulating synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in trans-synaptic signaling, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic cleft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in synaptic cleft NAS
Non-traceable Author Statement
more info
 PubMed 
part_of trans-synaptic protein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cerebellin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302356.2 → NP_001289285.1  cerebellin-2 precursor

    See identical proteins and their annotated locations for NP_001289285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000068863.4, ENSMUST00000068423.10
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

  2. NM_001361142.1 → NP_001348071.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

  3. NM_001361143.1 → NP_001348072.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

  4. NM_001361144.1 → NP_001348073.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000126810.2, ENSMUST00000169470.2
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

  5. NM_001361145.1 → NP_001348074.1  cerebellin-2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

  6. NM_172633.4 → NP_766221.1  cerebellin-2 precursor

    See identical proteins and their annotated locations for NP_766221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC115783, AK032112, AK076174, BM948793, BX523565
    Consensus CDS
    CCDS29388.1
    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000113695.2, ENSMUST00000122079.8
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    86727226..86736410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160955.1 → XP_036016848.1  cerebellin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BGU2
    Related
    ENSMUSP00000113996.2, ENSMUST00000122464.8
    Conserved Domains (1) summary
    cl23878
    Location:86 → 224
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGU2.1 GenPept UniProtKB/Swiss-Prot:Q8BGU2

Gene LinkOut

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