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LOC123833527 Sharpr-MPRA regulatory region 3090 [ Homo sapiens (human) ]

Gene ID: 123833527, updated on 10-Oct-2023

Summary

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Gene symbol
LOC123833527
Gene description
Sharpr-MPRA regulatory region 3090
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 24:Quies, heterochromatin/dead zone). [provided by RefSeq, Jan 2022]
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Genomic context

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Location:
6q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (114398545..114398839)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (115581703..115581997)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114719709..114720003)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HDAC2 and HS3ST5 antisense RNA 2 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 5 Neighboring gene RNA, 5S ribosomal pseudogene 213 Neighboring gene NANOG hESC enhancer GRCh37_chr6:114603304-114603805 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114640738-114641477 Neighboring gene uncharacterized LOC107986638 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:114683371-114683962 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:114683963-114684552 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1 pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114743417-114744081 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114742086-114742751 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114745558-114746227 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746228-114746898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114746899-114747567 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114747568-114748238 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114748909-114749578 Neighboring gene lncRNA periodontal mesenchymal stem cell osteogenesis related Neighboring gene NANOG hESC enhancer GRCh37_chr6:114885549-114886071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:115046932-115047452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:115047453-115047971 Neighboring gene RNA, U6 small nuclear 475, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_078181.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    114398545..114398839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    115581703..115581997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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