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Car11 carbonic anhydrase 11 [ Mus musculus (house mouse) ]

Gene ID: 12348, updated on 2-Nov-2024

Summary

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Official Symbol
Car11provided by MGI
Official Full Name
carbonic anhydrase 11provided by MGI
Primary source
MGI:MGI:1336193
See related
Ensembl:ENSMUSG00000003273 AllianceGenome:MGI:1336193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca11
Summary
Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; ear; eye; genitourinary system; and nervous system. Orthologous to human CA11 (carbonic anhydrase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 49.8), frontal lobe adult (RPKM 43.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Car11 in Genome Data Viewer
Location:
7 B3; 7 29.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45348537..45354106)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45699171..45704687)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 2 Neighboring gene predicted gene, 39008 Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene STARR-positive B cell enhancer ABC_E350 Neighboring gene D site albumin promoter binding protein Neighboring gene STARR-positive B cell enhancer ABC_E6545 Neighboring gene sphingosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene ribosomal protein L18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI. Taniuchi K, et al. Brain Res Mol Brain Res, 2002 Dec 30. PMID 12531530
  2. Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. Lovejoy DA, et al. Genomics, 1998 Dec 15. PMID 9878252
  3. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Verlander JW, et al. Am J Physiol Renal Physiol, 2003 Feb. PMID 12388412
  4. Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. Reibring CG, et al. PLoS One, 2014. PMID 24789143, Free PMC Article
  5. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Wu L, et al. Dev Dyn, 2013 Mar. PMID 23233153

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables carbonate dehydratase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbonic anhydrase-related protein 11
Names
CA-RP II
CA-RP XI
CA-XI
CARP XI
CARP-2
carbonic anhydrase-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368349.2 → NP_001355278.1  carbonic anhydrase-related protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167242
    UniProtKB/TrEMBL
    Q3USV1

  2. NM_009800.5 → NP_033930.1  carbonic anhydrase-related protein 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033930.1

    Status: VALIDATED

    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS21259.1
    UniProtKB/Swiss-Prot
    O70354, Q8VEA9
    UniProtKB/TrEMBL
    Q3USV1, Q541E9
    Related
    ENSMUSP00000003360.8, ENSMUST00000003360.10
    Conserved Domains (1) summary
    cd03121
    Location:48 → 304
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

RNA

  1. NR_177998.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167242

  2. NR_177999.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167242

  3. NR_178000.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167242

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45348537..45354106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540588.4 → XP_006540651.1  carbonic anhydrase-related protein 11 isoform X1

    UniProtKB/TrEMBL
    Q3USV1
    Conserved Domains (1) summary
    cd03121
    Location:48 → 304
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

  2. XM_006540589.3 → XP_006540652.1  carbonic anhydrase-related protein 11 isoform X2

    UniProtKB/TrEMBL
    Q3USV1
    Conserved Domains (1) summary
    cd03121
    Location:23 → 279
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70354.2 GenPept UniProtKB/Swiss-Prot:O70354

Gene LinkOut

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