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Camk2g calcium/calmodulin-dependent protein kinase II gamma [ Mus musculus (house mouse) ]

Gene ID: 12325, updated on 2-Nov-2024

Summary

Official Symbol
Camk2gprovided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase II gammaprovided by MGI
Primary source
MGI:MGI:88259
See related
Ensembl:ENSMUSG00000021820 AllianceGenome:MGI:88259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camkg
Summary
Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of neuron projection development and regulation of relaxation of cardiac muscle. Acts upstream of or within G1/S transition of mitotic cell cycle; calcium ion transport; and protein autophosphorylation. Located in postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 49.3), cerebellum adult (RPKM 39.7) and 26 other tissues See more
Orthologs
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Genomic context

See Camk2g in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20784943..20844225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20734873..20794157, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774 Neighboring gene predicted gene, 30108 Neighboring gene STARR-seq mESC enhancer starr_36120 Neighboring gene plasminogen activator, urokinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 5930429P18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of relaxation of cardiac muscle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of calcium- and calmodulin-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit gamma
Names
Ca2+/calmodulin-dependent protein kinase II
CaMK II
caMK-II subunit gamma
NP_001034227.1
NP_001034228.1
NP_001347115.1
NP_001411380.1
NP_001411381.1
NP_001411382.1
NP_001411383.1
NP_001411384.1
NP_001411385.1
NP_001411386.1
NP_001411387.1
NP_001411388.1
NP_001411389.1
NP_001411390.1
NP_848712.2
XP_006518556.1
XP_006518563.1
XP_030103477.1
XP_030103478.1
XP_030103479.1
XP_030103480.1
XP_030103481.1
XP_030103483.1
XP_030103484.1
XP_030103485.1
XP_030103486.1
XP_030103487.1
XP_030103488.1
XP_030103489.1
XP_036014315.1
XP_036014316.1
XP_036014317.1
XP_036014318.1
XP_036014319.1
XP_036014320.1
XP_036014321.1
XP_036014322.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039138.3NP_001034227.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

    See identical proteins and their annotated locations for NP_001034227.1

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS26855.1
    UniProtKB/TrEMBL
    A0A2I3BQP6
    Related
    ENSMUSP00000079298.7, ENSMUST00000080440.14
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001039139.3NP_001034228.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

    See identical proteins and their annotated locations for NP_001034228.1

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS26856.1
    UniProtKB/TrEMBL
    A0A2I3BQP6, Q6ZWS7
    Related
    ENSMUSP00000098398.4, ENSMUST00000100837.11
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:363490
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001360186.2NP_001347115.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121599
    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_001424451.1NP_001411380.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121599
  5. NM_001424452.1NP_001411381.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121599
  6. NM_001424453.1NP_001411382.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC121599
  7. NM_001424454.1NP_001411383.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC121599
  8. NM_001424455.1NP_001411384.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC121599
  9. NM_001424456.1NP_001411385.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC121599
  10. NM_001424457.1NP_001411386.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC121599
  11. NM_001424458.1NP_001411387.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC121599
  12. NM_001424459.1NP_001411388.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Related
    ENSMUSP00000154158.2, ENSMUST00000226630.2
  13. NM_001424460.1NP_001411389.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC121599
  14. NM_001424461.1NP_001411390.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC121599
  15. NM_178597.6NP_848712.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_848712.2

    Status: VALIDATED

    Source sequence(s)
    AC121599
    Consensus CDS
    CCDS26857.1
    UniProtKB/Swiss-Prot
    Q3U3H3, Q8VED3, Q923T9
    UniProtKB/TrEMBL
    A0A2I3BQP6
    Related
    ENSMUSP00000071720.7, ENSMUST00000071816.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:397524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RNA

  1. NR_188718.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121599
  2. NR_188719.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121599
  3. NR_188720.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121599
  4. NR_188721.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121599
  5. NR_188722.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121599

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20784943..20844225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247621.1XP_030103481.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X22

    Conserved Domains (2) summary
    pfam08332
    Location:292419
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006518493.4XP_006518556.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

    See identical proteins and their annotated locations for XP_006518556.1

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:422549
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. XM_030247620.2XP_030103480.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X21

    Conserved Domains (2) summary
    pfam08332
    Location:319446
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  4. XM_030247619.2XP_030103479.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X19

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    pfam08332
    Location:342469
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  5. XM_036158425.1XP_036014318.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X20

    Conserved Domains (2) summary
    pfam08332
    Location:330457
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  6. XM_030247617.2XP_030103477.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X17

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    pfam08332
    Location:353480
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  7. XM_030247618.2XP_030103478.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18

    Conserved Domains (2) summary
    pfam08332
    Location:351478
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  8. XM_006518500.5XP_006518563.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X16

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    pfam08332
    Location:374501
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:11221
    PKc_like; Protein Kinases, catalytic domain
  9. XM_030247623.2XP_030103483.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:234361
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  10. XM_030247625.2XP_030103485.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X26

    Conserved Domains (2) summary
    pfam08332
    Location:213340
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  11. XM_030247626.2XP_030103486.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X27

    Conserved Domains (2) summary
    pfam08332
    Location:211338
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  12. XM_030247624.2XP_030103484.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:234361
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  13. XM_030247628.2XP_030103488.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X29

    Conserved Domains (2) summary
    pfam08332
    Location:202329
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  14. XM_030247629.2XP_030103489.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X30

    Conserved Domains (2) summary
    pfam08332
    Location:179306
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  15. XM_036158426.1XP_036014319.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:234361
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain
  16. XM_036158422.1XP_036014315.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    pfam08332
    Location:419546
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:56266
    PKc_like; Protein Kinases, catalytic domain
  17. XM_036158429.1XP_036014322.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X31

    Conserved Domains (2) summary
    pfam08332
    Location:173300
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:152
    PKc_like; Protein Kinases, catalytic domain
  18. XM_036158423.1XP_036014316.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

    Conserved Domains (2) summary
    pfam08332
    Location:396523
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:56266
    PKc_like; Protein Kinases, catalytic domain
  19. XM_036158424.1XP_036014317.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

    UniProtKB/TrEMBL
    A0A2I3BQP6
    Conserved Domains (2) summary
    pfam08332
    Location:387514
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:56266
    PKc_like; Protein Kinases, catalytic domain
  20. XM_036158428.1XP_036014321.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X25

    UniProtKB/TrEMBL
    A0A286YCW8
    Conserved Domains (2) summary
    pfam08332
    Location:144271
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:152
    PKc_like; Protein Kinases, catalytic domain
  21. XM_030247627.2XP_030103487.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X28

    Conserved Domains (2) summary
    pfam08332
    Location:205332
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:152
    PKc_like; Protein Kinases, catalytic domain
  22. XM_036158427.1XP_036014320.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:234361
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1181
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003950821.2 RNA Sequence

  2. XR_004938372.1 RNA Sequence

  3. XR_003950818.2 RNA Sequence

  4. XR_874287.4 RNA Sequence