U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC123038189 Sharpr-MPRA regulatory region 765 [ Homo sapiens (human) ]

Gene ID: 123038189, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC123038189
Gene description
Sharpr-MPRA regulatory region 765
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 20:ReprD, Polycomb repression w. Duke DNase/promoter and conservation enriched) and K562 erythroleukemia cells (group: K562 Repressive non-DNase unmatched - State 13:Ctcf, distal CTCF/candidate insulator without open chromatin). [provided by RefSeq, Oct 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (135503627..135503921)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (138249429..138249723)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (135222469..135222763)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:134610984-134611623 Neighboring gene EPH receptor B1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:134660519-134661204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134723970-134724470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134724471-134724971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134737937-134738437 Neighboring gene uncharacterized LOC102724019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20577 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:134968182-134968385 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134976165-134976780 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134976781-134977396 Neighboring gene uncharacterized LOC105374122 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:135171489-135171996 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:135232323-135233522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:135377721-135378306 Neighboring gene uncharacterized LOC105374123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20578 Neighboring gene uncharacterized LOC105374124

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077320.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    135503627..135503921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    138249429..138249723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases