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F12 coagulation factor XII [ Varanus komodoensis (Komodo dragon) ]

Gene ID: 123034027, updated on 22-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
Gene type
protein coding
RefSeq status
MODEL
Organism
Varanus komodoensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
Orthologs
human mouse all
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Genomic context

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See F12 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
14
Annotation release Status Assembly Chr Location
100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025336345.1 (6319122..6336434)

NW_025336345.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene lysophosphatidic acid receptor 6-like Neighboring gene alpha-2Da adrenergic receptor-like Neighboring gene solute carrier family 34 member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_025336345 Unplaced Scaffold Reference ASM479886v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XII

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM479886v1

Genomic

  1. NW_025336345.1 Reference ASM479886v1

    Range
    6319122..6336434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044451060.1 → XP_044306995.1  coagulation factor XII isoform X1

    Conserved Domains (4) summary
    smart00059
    Location:43 → 83
    FN2; Fibronectin type 2 domain
    smart00130
    Location:210 → 292
    KR; Kringle domain
    cd00054
    Location:93 → 125
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:349 → 589
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_044451061.1 → XP_044306996.1  coagulation factor XII isoform X2

    Conserved Domains (4) summary
    smart00059
    Location:43 → 83
    FN2; Fibronectin type 2 domain
    smart00130
    Location:210 → 292
    KR; Kringle domain
    cd00054
    Location:93 → 125
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:298 → 448
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version

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