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MASP2 MBL associated serine protease 2 [ Varanus komodoensis (Komodo dragon) ]

Gene ID: 123030990, updated on 22-Mar-2024

Summary

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Gene symbol
MASP2
Gene description
MBL associated serine protease 2
Locus tag
EYD10_13999
See related
Ensembl:ENSVKKG00000013412
Gene type
protein coding
RefSeq status
MODEL
Organism
Varanus komodoensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
Orthologs
human mouse all
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Genomic context

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See MASP2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025336059.1 (3545858..3563141, complement)

NW_025336059.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene castor zinc finger 1 Neighboring gene somatostatin-2-like Neighboring gene TAR DNA binding protein Neighboring gene spermidine synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_025336059 Unplaced Scaffold Reference ASM479886v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mannan-binding lectin serine protease 2
Names
Mannan-binding lectin serine protease 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM479886v1

Genomic

  1. NW_025336059.1 Reference ASM479886v1

    Range
    3545858..3563141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044445372.1 → XP_044301307.1  mannan-binding lectin serine protease 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D2LD19
    Related
    ENSVKKP00000019819.1, ENSVKKT00000020306.1
    Conserved Domains (6) summary
    cd00033
    Location:369 → 435
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:303 → 364
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00042
    Location:31 → 137
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00179
    Location:141 → 184
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:187 → 298
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:449 → 689
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_044445373.1 → XP_044301308.1  mannan-binding lectin serine protease 2 isoform X2

    UniProtKB/TrEMBL
    A0A8D2LBW6
    Related
    ENSVKKP00000019820.1, ENSVKKT00000020307.1
    Conserved Domains (2) summary
    smart00042
    Location:31 → 137
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00179
    Location:141 → 184
    EGF_CA; Calcium-binding EGF-like domain
Nucleotide Protein
Heading Accession and Version

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