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CAPN3 calpain 3 [ Varanus komodoensis (Komodo dragon) ]

Gene ID: 123026806, updated on 22-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
Locus tag
EYD10_02567
See related
Ensembl:ENSVKKG00000007306
Gene type
protein coding
RefSeq status
MODEL
Organism
Varanus komodoensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
Also known as
Calpain-3
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025335761.1 (18851396..18881431, complement)

NW_025335761.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene uncharacterized LOC123026812 Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A Neighboring gene VPS39 subunit of HOPS complex Neighboring gene phospholipase A2 group IVF

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_025335761 Unplaced Scaffold Reference ASM479886v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM479886v1

Genomic

  1. NW_025335761.1 Reference ASM479886v1

    Range
    18851396..18881431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044436845.1 → XP_044292780.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A8D2JJM9
    Conserved Domains (3) summary
    smart00230
    Location:55 → 415
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:417 → 574
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:634 → 802
    EFh_PEF_CAPN3; Calcium-activated neutral

  2. XM_044436846.1 → XP_044292781.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A8D2JJM9
    Conserved Domains (3) summary
    smart00230
    Location:55 → 415
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:417 → 574
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:599 → 767
    EFh_PEF_CAPN3; Calcium-activated neutral

  3. XM_044436847.1 → XP_044292782.1  calpain-3 isoform X3

    Conserved Domains (3) summary
    cd15897
    Location:132 → 160
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:132 → 300
    EFh_PEF; The penta-EF hand (PEF) family
    cl00165
    Location:7 → 72
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

  4. XM_044436848.1 → XP_044292783.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A8D2J7G7
    Related
    ENSVKKP00000010470.1, ENSVKKT00000010725.1
    Conserved Domains (2) summary
    cd15897
    Location:31 → 60
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1 → 156
    EFh_PEF; The penta-EF hand (PEF) family
Nucleotide Protein
Heading Accession and Version

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