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LRP4 LDL receptor related protein 4 [ Varanus komodoensis (Komodo dragon) ]

Gene ID: 123026331, updated on 22-Mar-2024

Summary

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Gene symbol
LRP4
Gene description
LDL receptor related protein 4
Locus tag
EYD10_02469
See related
Ensembl:ENSVKKG00000016406
Gene type
protein coding
RefSeq status
MODEL
Organism
Varanus komodoensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus
Also known as
LRP4_1; LRP4_2; Lrp4_0
Orthologs
human mouse all
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Genomic context

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See LRP4 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
39
Annotation release Status Assembly Chr Location
100 current ASM479886v1 (GCF_004798865.1) Unplaced Scaffold NW_025335761.1 (12108901..12229807, complement)

NW_025335761.1Genomic Context describing neighboring genes Neighboring gene prothrombin-like Neighboring gene small nucleolar RNA SNORD67 Neighboring gene cytoskeleton associated protein 5 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene ARF GTPase activating protein 2 Neighboring gene THAP domain containing 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_025335761 Unplaced Scaffold Reference ASM479886v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 4
Names
Low-density lipoprotein receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Varanus komodoensis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM479886v1

Genomic

  1. NW_025335761.1 Reference ASM479886v1

    Range
    12108901..12229807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044435818.1 → XP_044291753.1  low-density lipoprotein receptor-related protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A8D2LN09
    Conserved Domains (4) summary
    smart00135
    Location:476 → 516
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:283 → 317
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:746 → 779
    NHL; NHL repeat [structural motif]
    cl18310
    Location:746 → 941
    NHL; NHL repeat unit of beta-propeller proteins

  2. XM_044435817.1 → XP_044291752.1  low-density lipoprotein receptor-related protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8D2LMY5
    Conserved Domains (5) summary
    smart00135
    Location:478 → 518
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:368 → 407
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:243 → 277
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:748 → 781
    NHL; NHL repeat [structural motif]
    cl18310
    Location:748 → 943
    NHL; NHL repeat unit of beta-propeller proteins

  3. XM_044435815.1 → XP_044291750.1  low-density lipoprotein receptor-related protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8D2LQ76
    Conserved Domains (5) summary
    smart00135
    Location:518 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:408 → 447
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:283 → 317
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:787 → 820
    NHL; NHL repeat [structural motif]
    cl18310
    Location:787 → 982
    NHL; NHL repeat unit of beta-propeller proteins

  4. XM_044435814.1 → XP_044291749.1  low-density lipoprotein receptor-related protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8D2LQ76
    Conserved Domains (5) summary
    smart00135
    Location:518 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:408 → 447
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:283 → 317
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:788 → 821
    NHL; NHL repeat [structural motif]
    cl18310
    Location:788 → 983
    NHL; NHL repeat unit of beta-propeller proteins

  5. XM_044435820.1 → XP_044291755.1  low-density lipoprotein receptor-related protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8D2LN07
    Related
    ENSVKKP00000024925.1, ENSVKKT00000025533.1
    Conserved Domains (5) summary
    smart00135
    Location:518 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:408 → 447
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:283 → 317
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:788 → 821
    NHL; NHL repeat [structural motif]
    cl18310
    Location:788 → 983
    NHL; NHL repeat unit of beta-propeller proteins

  6. XM_044435819.1 → XP_044291754.1  low-density lipoprotein receptor-related protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8D2LN07
    Related
    ENSVKKP00000024938.1, ENSVKKT00000025546.1
    Conserved Domains (5) summary
    smart00135
    Location:518 → 558
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:408 → 447
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:283 → 317
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:788 → 821
    NHL; NHL repeat [structural motif]
    cl18310
    Location:788 → 983
    NHL; NHL repeat unit of beta-propeller proteins
Nucleotide Protein
Heading Accession and Version

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