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LOC123002303 Sharpr-MPRA regulatory region 6361 [ Homo sapiens (human) ]

Gene ID: 123002303, updated on 10-Oct-2023

Summary

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Gene symbol
LOC123002303
Gene description
Sharpr-MPRA regulatory region 6361
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Repressive non-DNase unmatched - State 3:PromF, promoter flanking). [provided by RefSeq, Oct 2021]
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Genomic context

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See LOC123002303 in Genome Data Viewer
Location:
3p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71390278..71390572)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71426955..71427249)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71439429..71439723)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene forkhead box P1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71354949-71355604 Neighboring gene FOXP1 antisense RNA 1 Neighboring gene uncharacterized LOC124906248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20060 Neighboring gene VISTA enhancer hs1116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:71463501-71464005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20062 Neighboring gene Sharpr-MPRA regulatory region 10822 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71546600-71547538 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:71552767-71553966 Neighboring gene Sharpr-MPRA regulatory region 15380 Neighboring gene VISTA enhancer hs1149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14520 Neighboring gene Sharpr-MPRA regulatory region 11865 Neighboring gene microRNA 1284 Neighboring gene FOXP1 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_077260.1 

    Range
    101..395
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    71390278..71390572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    71426955..71427249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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