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epm2a EPM2A glucan phosphatase, laforin [ Thunnus albacares (yellowfin tuna) ]

Gene ID: 123000013, updated on 22-Mar-2024

Summary

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Gene symbol
epm2a
Gene description
EPM2A glucan phosphatase, laforin
See related
EnsemblRapid:ENSTABG00005015834
Gene type
protein coding
RefSeq status
MODEL
Organism
Thunnus albacares
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Pelagiaria; Scombriformes; Scombridae; Thunnus
Orthologs
human zebrafish all
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Genomic context

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See epm2a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
100 current fThuAlb1.1 (GCF_914725855.1) 16 NC_058121.1 (12423193..12429849, complement)

Chromosome 16 - NC_058121.1Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene uncharacterized LOC123000017 Neighboring gene uncharacterized LOC123000018 Neighboring gene hydroperoxide isomerase ALOXE3-like Neighboring gene hydroperoxide isomerase ALOXE3-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_058121.1 Chromosome 16 Reference fThuAlb1.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substitutions in the Glycogenin-1 Gene Are Associated with the Evolution of Endothermy in Sharks and Tunas. Ciezarek AG, et al. Genome Biol Evol, 2016 Oct 5. PMID 27614233, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables carbohydrate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables starch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
laforin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Thunnus albacares Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fThuAlb1.1

Genomic

  1. NC_058121.1 Reference fThuAlb1.1

    Range
    12423193..12429849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_044377443.1 → XP_044233378.1  laforin

    Related
    ENSTABP00005040130.1, ENSTABT00005040603.1
    Conserved Domains (2) summary
    cd05806
    Location:1 → 111
    CBM20_laforin; Laforin protein tyrosine phosphatase, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Laforin, encoded by the EPM2A gene, is a dual-specificity phosphatase that dephosphorylates complex carbohydrates. Mutations in the gene encoding ...
    cd14526
    Location:137 → 295
    DSP_laforin-like; dual specificity phosphatase domain of laforin and similar domains
Nucleotide Protein
Heading Accession and Version

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