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TPPP2 tubulin polymerization promoting protein family member 2 [ Homo sapiens (human) ]

Gene ID: 122664, updated on 3-Apr-2024

Summary

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Official Symbol
TPPP2provided by HGNC
Official Full Name
tubulin polymerization promoting protein family member 2provided by HGNC
Primary source
HGNC:HGNC:19293
See related
Ensembl:ENSG00000179636 MIM:616956; AllianceGenome:HGNC:19293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; CT152; C14orf8; p25beta
Summary
Enables tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 37.8) and salivary gland (RPKM 2.8) See more
Orthologs
mouse all
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Genomic context

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See TPPP2 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21024299..21036352)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15221665..15233755)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21498376..21500974)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21467511-21468710 Neighboring gene solute carrier family 39 member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873 Neighboring gene NDRG family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5576 Neighboring gene microRNA 6717 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21507297-21507461 Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. Zhu F, et al. J Cell Mol Med, 2019 Apr. PMID 30680919, Free PMC Article
  2. Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Vincze O, et al. Biochemistry, 2006 Nov 21. PMID 17105200
  3. p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies. Lindersson E, et al. J Biol Chem, 2005 Feb 18. PMID 15590652
  4. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Zeng H, et al. Elife, 2019 Nov 19. PMID 31741433, Free PMC Article
  5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AL161668.5

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tubulin polymerization-promoting protein family member 2
Names
TPPP/p18
protein p25-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173846.5 → NP_776245.2  tubulin polymerization-promoting protein family member 2

    See identical proteins and their annotated locations for NP_776245.2

    Status: VALIDATED

    Source sequence(s)
    AL161668, AW135537, BC038970, DB458250
    Consensus CDS
    CCDS9566.1
    UniProtKB/Swiss-Prot
    P59282, Q2VYF3
    Related
    ENSP00000317595.6, ENST00000321760.11
    Conserved Domains (1) summary
    pfam05517
    Location:6 → 161
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21024299..21036352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020966.2 → XP_016876455.1  tubulin polymerization-promoting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    P59282, Q2VYF3
    Conserved Domains (1) summary
    pfam05517
    Location:6 → 161
    p25-alpha; p25-alpha

  2. XM_011536416.2 → XP_011534718.1  tubulin polymerization-promoting protein family member 2 isoform X2

    UniProtKB/TrEMBL
    D6R9S2
    Related
    ENSP00000423171.1, ENST00000472458.5
    Conserved Domains (1) summary
    pfam05517
    Location:8 → 109
    p25-alpha; p25-alpha

  3. XM_011536420.3 → XP_011534722.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534722.1

    UniProtKB/TrEMBL
    H0Y8L2
    Conserved Domains (1) summary
    pfam05517
    Location:8 → 109
    p25-alpha; p25-alpha

  4. XM_011536417.3 → XP_011534719.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534719.1

    UniProtKB/TrEMBL
    H0Y8L2
    Conserved Domains (1) summary
    pfam05517
    Location:8 → 109
    p25-alpha; p25-alpha

  5. XM_011536418.2 → XP_011534720.1  tubulin polymerization-promoting protein family member 2 isoform X3

    See identical proteins and their annotated locations for XP_011534720.1

    UniProtKB/TrEMBL
    H0Y8L2
    Related
    ENSP00000421438.1, ENST00000481535.5
    Conserved Domains (1) summary
    pfam05517
    Location:8 → 109
    p25-alpha; p25-alpha

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15221665..15233755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375353.1 → XP_054231328.1  tubulin polymerization-promoting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    P59282, Q2VYF3

  2. XM_054375352.1 → XP_054231327.1  tubulin polymerization-promoting protein family member 2 isoform X1

    UniProtKB/Swiss-Prot
    P59282, Q2VYF3

  3. XM_054375354.1 → XP_054231329.1  tubulin polymerization-promoting protein family member 2 isoform X2

  4. XM_054375357.1 → XP_054231332.1  tubulin polymerization-promoting protein family member 2 isoform X3

  5. XM_054375355.1 → XP_054231330.1  tubulin polymerization-promoting protein family member 2 isoform X3

  6. XM_054375356.1 → XP_054231331.1  tubulin polymerization-promoting protein family member 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59282.2 GenPept UniProtKB/Swiss-Prot:P59282

Gene LinkOut

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