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cbl Cbl proto-oncogene, E3 ubiquitin protein ligase [ Chiloscyllium plagiosum (whitespotted bambooshark) ]

Gene ID: 122541123, updated on 22-Mar-2024

Summary

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Gene symbol
cbl
Gene description
Cbl proto-oncogene, E3 ubiquitin protein ligase
Gene type
protein coding
RefSeq status
MODEL
Organism
Chiloscyllium plagiosum
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Orectolobiformes; Hemiscylliidae; Chiloscyllium
Orthologs
human zebrafish all
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Genomic context

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See cbl in Genome Data Viewer
Location:
chromosome: 36
Exon count:
17
Annotation release Status Assembly Chr Location
100 current ASM401019v2 (GCF_004010195.1) 36 NC_057745.1 (37434666..37705837)

Chromosome 36 - NC_057745.1Genomic Context describing neighboring genes Neighboring gene hepatic and glial cell adhesion molecule a Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene constitutive coactivator of PPAR-gamma-like protein 2 Neighboring gene transfer RNA methionine (anticodon CAU) Neighboring gene cell surface glycoprotein MUC18-like Neighboring gene uncharacterized LOC122541127 Neighboring gene uncharacterized LOC122541128

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_057745.1 Chromosome 36 Reference ASM401019v2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chiloscyllium plagiosum Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM401019v2 Primary Assembly

Genomic

  1. NC_057745.1 Reference ASM401019v2 Primary Assembly

    Range
    37434666..37705837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_043677729.1 → XP_043533664.1  E3 ubiquitin-protein ligase CBL isoform X3

    Conserved Domains (3) summary
    cd09920
    Location:243 → 339
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:820 → 859
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:349 → 414
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  2. XM_043677727.1 → XP_043533662.1  E3 ubiquitin-protein ligase CBL isoform X1

    Conserved Domains (4) summary
    cd09920
    Location:243 → 339
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PHA03247
    Location:467 → 729
    PHA03247; large tegument protein UL36; Provisional
    cd14393
    Location:864 → 903
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:349 → 414
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

  3. XM_043677728.1 → XP_043533663.1  E3 ubiquitin-protein ligase CBL isoform X2

    Conserved Domains (4) summary
    cd09920
    Location:243 → 339
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PHA03247
    Location:467 → 715
    PHA03247; large tegument protein UL36; Provisional
    cd14393
    Location:850 → 889
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:349 → 414
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
Nucleotide Protein
Heading Accession and Version

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