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C14orf28 chromosome 14 open reading frame 28 [ Homo sapiens (human) ]

Gene ID: 122525, updated on 5-Mar-2024

Summary

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Official Symbol
C14orf28provided by HGNC
Official Full Name
chromosome 14 open reading frame 28provided by HGNC
Primary source
HGNC:HGNC:19834
See related
Ensembl:ENSG00000179476 AllianceGenome:HGNC:19834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRIP1; DRIP-1; c14_5270
Expression
Ubiquitous expression in endometrium (RPKM 4.2), testis (RPKM 3.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (44897275..44907257)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (39089234..39099216)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45366478..45376460)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene DET1 and DDB1 associated 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:45366797-45367296 Neighboring gene uncharacterized LOC101927418 Neighboring gene Ras related GTP binding A pseudogene 1 Neighboring gene kelch like family member 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8295 Neighboring gene H3K27ac hESC enhancers GRCh37_chr14:45430821-45431335 and GRCh37_chr14:45431336-45431850 Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8297 Neighboring gene Sharpr-MPRA regulatory region 2603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer. Yang X, et al. Mol Cell Biochem, 2017 Oct. PMID 28455792
  2. Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. Zhan L, et al. Neuropathol Appl Neurobiol, 2011 Feb. PMID 20874815
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our data suggest: (i) C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder
    Title: Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

General protein information

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Preferred Names
uncharacterized protein C14orf28
Names
dopamine receptor interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017923.2 → NP_001017923.1  uncharacterized protein C14orf28

    See identical proteins and their annotated locations for NP_001017923.1

    Status: VALIDATED

    Source sequence(s)
    AL049870, BM849739, BU624091
    Consensus CDS
    CCDS32069.1
    UniProtKB/Swiss-Prot
    Q4W4Y0
    UniProtKB/TrEMBL
    Q8N0U0
    Related
    ENSP00000326846.3, ENST00000325192.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    44897275..44907257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430915.1 → XP_047286871.1  uncharacterized protein C14orf28 isoform X1

  2. XM_011536408.1 → XP_011534710.1  uncharacterized protein C14orf28 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    39089234..39099216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375344.1 → XP_054231319.1  uncharacterized protein C14orf28 isoform X1

  2. XM_054375345.1 → XP_054231320.1  uncharacterized protein C14orf28 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4W4Y0.1 GenPept UniProtKB/Swiss-Prot:Q4W4Y0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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