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TMSB15C thymosin beta 15C [ Homo sapiens (human) ]

Gene ID: 122394733, updated on 2-Nov-2024

Summary

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Official Symbol
TMSB15Cprovided by HGNC
Official Full Name
thymosin beta 15Cprovided by HGNC
Primary source
HGNC:HGNC:55173
See related
Ensembl:ENSG00000269226 AllianceGenome:HGNC:55173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMSB15B
Summary
Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See TMSB15C in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (104072887..104076236, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_004070885.1 (209303..212652, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985662 Neighboring gene H2B.W histone 3, pseudogene Neighboring gene DPPA3 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103349345-103349844 Neighboring gene solute carrier family 25 member 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20923 Neighboring gene zinc finger CCHC-type containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. Banyard J, et al. Genes Chromosomes Cancer, 2009 Jun. PMID 19296525, Free PMC Article
  2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thymosin beta-15C
Names
thymosin beta 15B-like
thymosin beta-15B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395930.1 → NP_001382859.1  thymosin beta-15C

    Status: VALIDATED

    Source sequence(s)
    AC234783
    Consensus CDS
    CCDS94644.1
    UniProtKB/Swiss-Prot
    A8K614, P0CG34, P0CG35, P0DX04, Q99406
    Related
    ENSP00000472749.1, ENST00000598087.4
    Conserved Domains (1) summary
    pfam01290
    Location:3 → 39
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    104072887..104076236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG35.1 GenPept UniProtKB/Swiss-Prot:P0CG35
P0DX04.1 GenPept UniProtKB/Swiss-Prot:P0DX04

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.