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LOC122128440 Sharpr-MPRA regulatory region 723 [ Homo sapiens (human) ]

Gene ID: 122128440, updated on 10-Oct-2023

Summary

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Gene symbol
LOC122128440
Gene description
Sharpr-MPRA regulatory region 723
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional repressive element by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Repressive DNase unmatched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, Jul 2021]
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Genomic context

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See LOC122128440 in Genome Data Viewer
Location:
1q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155598978..155599272)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154737545..154737839)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155568769..155569063)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929703 Neighboring gene misato mitochondrial distribution and morphology regulator 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155546798-155546935 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155556739-155556902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155560641-155561220 Neighboring gene claudin 6 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155569297-155569949 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155569950-155570603 Neighboring gene death associated protein 3 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155578996-155579870 Neighboring gene uncharacterized LOC105371452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155579871-155580745 Neighboring gene gon-4 like pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155604951-155605710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155605711-155606471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155606472-155607231

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_076460.1 

    Range
    101..395
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155598978..155599272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154737545..154737839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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