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Chic1 cysteine-rich hydrophobic domain 1 [ Mus musculus (house mouse) ]

Gene ID: 12212, updated on 2-Nov-2024

Summary

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Official Symbol
Chic1provided by MGI
Official Full Name
cysteine-rich hydrophobic domain 1provided by MGI
Primary source
MGI:MGI:1344694
See related
Ensembl:ENSMUSG00000031327 AllianceGenome:MGI:1344694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brx; Gm10454
Summary
Predicted to be located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including central nervous system; metanephros; and retina. Orthologous to human CHIC1 (cysteine rich hydrophobic domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 3.3), cerebellum adult (RPKM 3.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Chic1 in Genome Data Viewer
Location:
X D; X 46.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102400009..102452698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103356403..103409092)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47688 Neighboring gene caudal type homeobox 4 Neighboring gene predicted gene 9516 Neighboring gene testis specific X-linked gene Neighboring gene STARR-seq mESC enhancer starr_47691 Neighboring gene origin of replication in Tsix Neighboring gene X (inactive)-specific transcript, opposite strand Neighboring gene origin of replication in exon 1 of Xist Neighboring gene inactive X specific transcripts Neighboring gene predicted gene 14861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brx is essential for the expression of nfat5 in response to osmotic stress.
    Title: Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • B930075F07

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteine-rich hydrophobic domain-containing protein 1
Names
brain X-linked protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009767.3 → NP_033897.1  cysteine-rich hydrophobic domain-containing protein 1

    See identical proteins and their annotated locations for NP_033897.1

    Status: VALIDATED

    Source sequence(s)
    AL669964
    Consensus CDS
    CCDS53165.1
    UniProtKB/Swiss-Prot
    O08904, Q8CBW7, Q8K3S5
    UniProtKB/TrEMBL
    A2RT09, Q3UX08
    Related
    ENSMUSP00000112246.3, ENSMUST00000116547.3
    Conserved Domains (1) summary
    pfam10256
    Location:108 → 140
    Erf4; Golgin subfamily A member 7/ERF4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    102400009..102452698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161794.1 → XP_036017687.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam10256
    Location:108 → 140
    Erf4; Golgin subfamily A member 7/ERF4 family

  2. XM_006527760.5 → XP_006527823.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3UX08
    Conserved Domains (1) summary
    pfam10256
    Location:108 → 140
    Erf4; Golgin subfamily A member 7/ERF4 family

  3. XM_036161795.1 → XP_036017688.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    pfam10256
    Location:108 → 140
    Erf4; Golgin subfamily A member 7/ERF4 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBW7.2 GenPept UniProtKB/Swiss-Prot:Q8CBW7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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