U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121852949 Sharpr-MPRA regulatory region 3582 [ Homo sapiens (human) ]

Gene ID: 121852949, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121852949
Gene description
Sharpr-MPRA regulatory region 3582
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin). [provided by RefSeq, Jul 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (72727690..72727984)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (73601050..73601343)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (70723829..70724123)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371887 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:70662937-70663580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70663581-70664223 Neighboring gene solute carrier family 39 member 11 Neighboring gene RN7SK pseudogene 180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:70682597-70683097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70715406-70716084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70716085-70716762 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:70717445-70717660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70738945-70739482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70739483-70740019 Neighboring gene small Cajal body-specific RNA 24 Neighboring gene Sharpr-MPRA regulatory region 3335 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:70943638-70944837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70947920-70948848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70948849-70949777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70949987-70950548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:70950549-70951109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:70974043-70974543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12684 Neighboring gene autophagy related 12 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_076056.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    72727690..72727984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    73601050..73601343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases