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LOC121847965 Sharpr-MPRA regulatory region 1628 [ Homo sapiens (human) ]

Gene ID: 121847965, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121847965
Gene description
Sharpr-MPRA regulatory region 1628
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin). [provided by RefSeq, Jul 2021]
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Genomic context

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See LOC121847965 in Genome Data Viewer
Location:
15q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101006984..101007278)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (98761645..98761939)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101547189..101547483)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101420568-101421082 Neighboring gene ALDH1A3 antisense RNA 1 Neighboring gene aldehyde dehydrogenase 1 family member A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101458234-101458826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101460013-101460604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101464364-101464864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101464865-101465365 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101466469-101466662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101469523-101470476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10178 Neighboring gene leucine rich repeat kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101535857-101536844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10182 Neighboring gene Sharpr-MPRA regulatory region 13394 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:101567313-101568512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101568957-101569509 Neighboring gene uncharacterized LOC105371026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101586279-101586964 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:101587260-101587760 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:101587761-101588261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101588923-101589446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101588398-101588922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101593635-101594255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101602418-101603083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101603084-101603748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101607739-101608404 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101609069-101609734 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101609735-101610398 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101610353-101610519 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101616303-101616866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101616867-101617428 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101617993-101618554 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101618555-101619118 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101619119-101619680 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101619681-101620242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101641875-101642662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101642663-101643449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101652194-101652980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101658577-101659078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10185 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101671452-101671651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10188 Neighboring gene uncharacterized LOC124903565

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075991.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    101006984..101007278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    98761645..98761939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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