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LOC121740695 Sharpr-MPRA regulatory region 15278 [ Homo sapiens (human) ]

Gene ID: 121740695, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121740695
Gene description
Sharpr-MPRA regulatory region 15278
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin). [provided by RefSeq, Jun 2021]
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Genomic context

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See LOC121740695 in Genome Data Viewer
Location:
7q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (120792075..120792369)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (122107404..122107698)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120432129..120432423)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375477 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:119896333-119897012 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:119897013-119897691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26551 Neighboring gene potassium voltage-gated channel subfamily D member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26554 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:120142038-120142659 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:120162507-120163318 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:120161695-120162506 Neighboring gene RNA, U6 small nuclear 581, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr7:120422555-120423072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18572 Neighboring gene tetraspanin 12 Neighboring gene uncharacterized LOC124901733 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:120497141-120497360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18573 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:120508165-120508289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26555 Neighboring gene uncharacterized LOC124901734 Neighboring gene inhibitor of growth family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075757.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    120792075..120792369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    122107404..122107698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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