U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121627910 Sharpr-MPRA regulatory region 14118 [ Homo sapiens (human) ]

Gene ID: 121627910, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121627910
Gene description
Sharpr-MPRA regulatory region 14118
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 10:DNaseD, primarily Duke DNase, candidate regulatory elements in more likely repressive locations). [provided by RefSeq, Jun 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (51366212..51366506)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (53136807..53137101)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49982749..49983043)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372661 Neighboring gene ribosomal protein SA pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13040 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838165-49838839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13039 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49838840-49839513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49853584-49854170 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:49874837-49876036 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49922777-49923737 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49927461-49928450 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:49928451-49929439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49938175-49938676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49944615-49945493 Neighboring gene uncharacterized LOC124904930 Neighboring gene uncharacterized LOC105372663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18110 Neighboring gene Sharpr-MPRA regulatory region 9422 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:50039818-50040650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50041537-50042129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18111 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:50051304-50052503 Neighboring gene nuclear factor of activated T cells 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50063011-50064210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50067417-50067918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50072771-50073376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:50079139-50080099 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:50103914-50105113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50105077-50105578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18112 Neighboring gene microRNA 3194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:50149441-50150640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50157559-50158228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50186888-50187388 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:50224727-50225926 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:50226387-50226540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50240809-50241341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:50247413-50248612 Neighboring gene Sharpr-MPRA regulatory region 9373 Neighboring gene ATPase phospholipid transporting 9A (putative) Neighboring gene Sharpr-MPRA regulatory region 11561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:50315099-50315599 Neighboring gene Sharpr-MPRA regulatory region 2244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50318515-50319015 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:50321824-50322382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50323455-50323954 Neighboring gene NANOG hESC enhancer GRCh37_chr20:50327032-50327577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:50329473-50329983 Neighboring gene ribosomal protein L29 pseudogene 35

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075101.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    51366212..51366506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    53136807..53137101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases