U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121587566 Sharpr-MPRA regulatory region 13594 [ Homo sapiens (human) ]

Gene ID: 121587566, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121587566
Gene description
Sharpr-MPRA regulatory region 13594
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase matched - State 17:Gen3', transcription 3' end of genes, highly expressed, more exonic). [provided by RefSeq, Jun 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88589521..88589815)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94657119..94657413)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88655929..88656223)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein, FOG family member 1 Neighboring gene ZFPM1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88591868-88592455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88592456-88593042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88593270-88594010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88594011-88594750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88599832-88600392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88600393-88600954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88606102-88606704 Neighboring gene ZC3H18 antisense RNA 1 (head to head) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11356 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88673559-88674059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88676553-88677498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694002-88694718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694719-88695433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88701182-88702111 Neighboring gene uncharacterized LOC124903755 Neighboring gene interleukin 17C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074853.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    88589521..88589815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    94657119..94657413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases