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LOC121587561 Sharpr-MPRA regulatory region 14271 [ Homo sapiens (human) ]

Gene ID: 121587561, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121587561
Gene description
Sharpr-MPRA regulatory region 14271
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 20:ReprD, Polycomb repression w. Duke DNase/promoter and conservation enriched). [provided by RefSeq, Jun 2021]
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Genomic context

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See LOC121587561 in Genome Data Viewer
Location:
16q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (72938850..72939144)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (78756641..78756935)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (72972749..72973043)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72879311-72879810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7689 Neighboring gene uncharacterized LOC124903715 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:72910943-72912142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72912157-72912658 Neighboring gene RNA, U7 small nuclear 71 pseudogene Neighboring gene zinc finger homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72923795-72924295 Neighboring gene Sharpr-MPRA regulatory region 11593 Neighboring gene VISTA enhancer hs16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72995175-72995675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73049174-73049674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11101 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:73066446-73067008 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:73070205-73071057 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:73069350-73070204 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:73074111-73074623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:73078457-73078957 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:73081321-73081856 Neighboring gene uncharacterized LOC124903719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:73082393-73082928 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:73087036-73087536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:73089102-73089614 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:73087537-73088037 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:73091454-73092186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7694 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:73098351-73098972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73126852-73127352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73127353-73127853 Neighboring gene hepatocellular carcinoma associated transcript 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074848.1 

    Range
    101..395
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    72938850..72939144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    78756641..78756935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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