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HELZ2 helicase with zinc finger 2 [ Vulpes lagopus (Arctic fox) ]

Gene ID: 121477918, updated on 22-Mar-2024

Summary

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Gene symbol
HELZ2
Gene description
helicase with zinc finger 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Vulpes lagopus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes
Orthologs
human mouse all
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Genomic context

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See HELZ2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
22
Annotation release Status Assembly Chr Location
100 current ASM1834538v1 (GCF_018345385.1) 18 NC_054841.1 (520332..544051)

Chromosome 18 - NC_054841.1Genomic Context describing neighboring genes Neighboring gene stathmin 3 Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene 60S ribosomal protein L32-like Neighboring gene tyrosine-protein kinase Srms-like Neighboring gene fibronectin type III domain containing 11 Neighboring gene protein-tyrosine kinase 6-like Neighboring gene collagen alpha-1(III) chain-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_054841.1 Chromosome 18 Reference ASM1834538v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
helicase with zinc finger domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Vulpes lagopus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1834538v1 Primary Assembly

Genomic

  1. NC_054841.1 Reference ASM1834538v1 Primary Assembly

    Range
    520332..544051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041732474.1 → XP_041588408.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18808
    Location:2767 → 2968
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2493 → 2766
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl39058
    Location:1430 → 1740
    RNB; RNB domain

  2. XM_041732476.1 → XP_041588410.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18808
    Location:2767 → 2968
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2493 → 2766
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl39058
    Location:1430 → 1740
    RNB; RNB domain

  3. XM_041732477.1 → XP_041588411.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18808
    Location:2767 → 2968
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2493 → 2766
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl39058
    Location:1430 → 1740
    RNB; RNB domain

  4. XM_041732478.1 → XP_041588412.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18808
    Location:2767 → 2968
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2493 → 2766
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl39058
    Location:1430 → 1740
    RNB; RNB domain

  5. XM_041732479.1 → XP_041588413.1  helicase with zinc finger domain 2 isoform X2

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    TIGR00376
    Location:2374 → 2943
    TIGR00376; DNA helicase, putative
    cd18808
    Location:1003 → 1191
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2459 → 2732
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  6. XM_041732475.1 → XP_041588409.1  helicase with zinc finger domain 2 isoform X1

    Conserved Domains (6) summary
    smart00955
    Location:1616 → 1972
    RNB; This domain is the catalytic domain of ribonuclease II
    cd18808
    Location:2767 → 2968
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18040
    Location:2493 → 2766
    DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
    cl26593
    Location:1206 → 1357
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
    cl28899
    Location:771 → 1000
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    cl39058
    Location:1430 → 1740
    RNB; RNB domain
Nucleotide Protein Strain
Heading Accession and Version

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