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LOC121392941 Sharpr-MPRA regulatory region 4637 [ Homo sapiens (human) ]

Gene ID: 121392941, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121392941
Gene description
Sharpr-MPRA regulatory region 4637
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase matched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, May 2021]
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Genomic context

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Location:
11q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114215887..114216181)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114226263..114226557)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114086609..114086903)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902760 Neighboring gene uncharacterized LOC124902759 Neighboring gene uncharacterized LOC124902761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113906845-113907785 Neighboring gene Sharpr-MPRA regulatory region 6346 Neighboring gene Sharpr-MPRA regulatory region 5585 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962252-113962768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962769-113963283 Neighboring gene MPRA-validated peak1475 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030299-114030800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030801-114031300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114034953-114035454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114035455-114035954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083238-114083738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083739-114084239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114111177-114111676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114128337-114128865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:114166597-114167097 Neighboring gene nicotinamide N-methyltransferase Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074598.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    114215887..114216181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    114226263..114226557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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