U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121366023 Sharpr-MPRA regulatory region 10302 [ Homo sapiens (human) ]

Gene ID: 121366023, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121366023
Gene description
Sharpr-MPRA regulatory region 10302
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating non-DNase unmatched - State 8:EnhW, candidate weak enhancer and open chromatin). [provided by RefSeq, May 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123470270..123470564)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135668137..135668452)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (126232549..126232843)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126116439-126116938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126120157-126120824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126124971-126125833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126128307-126128870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126130279-126130928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126137983-126138601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126138602-126139219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141215-126141716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141717-126142216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28941 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126149353-126149548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126160204-126160704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126164885-126165506 Neighboring gene crumbs cell polarity complex component 2 Neighboring gene DENN domain containing 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126181680-126182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126182181-126182681 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126185399-126186000 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126188501-126188713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28942 Neighboring gene microRNA 601 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126244597-126245462 Neighboring gene microRNA 7150 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:126323227-126323788 Neighboring gene uncharacterized LOC105376266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20251

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074373.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    123470270..123470564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    135668137..135668452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases