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Bglap3 bone gamma-carboxyglutamate protein 3 [ Mus musculus (house mouse) ]

Gene ID: 12095, updated on 2-Nov-2024

Summary

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Official Symbol
Bglap3provided by MGI
Official Full Name
bone gamma-carboxyglutamate protein 3provided by MGI
Primary source
MGI:MGI:88155
See related
Ensembl:ENSMUSG00000074489 AllianceGenome:MGI:88155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORG; OC-X; mOC-X; Bglap-rs1
Summary
Predicted to enable hydroxyapatite binding activity. Predicted to be a structural constituent of bone. Predicted to be involved in bone development and osteoblast differentiation. Predicted to be located in several cellular components, including dendrite; extracellular space; and perikaryon. Predicted to be active in extracellular region. Is expressed in several structures, including brain; cranial ganglion; foregut; musculoskeletal system; and nasal cavity epithelium. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 48.2), placenta adult (RPKM 30.7) and 2 other tissues See more
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Genomic context

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See Bglap3 in Genome Data Viewer
Location:
3 F1; 3 38.81 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88275923..88280048, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88368616..88372741, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene progestin and adipoQ receptor family member VI Neighboring gene Bglap2 promoter region Neighboring gene predicted gene, 21956 Neighboring gene bone gamma-carboxyglutamate protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of an RNA sequence within an intracisternal-A particle element able to replace Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. Tabernero C, et al. J Virol, 1997 Jan. PMID 8985327, Free PMC Article
  2. Evidence that the mouse osteocalcin-related gene does not encode nephrocalcin. Petrucci M, et al. Nephron Exp Nephrol, 2006. PMID 16902318
  3. Preferential expression of osteocalcin-related protein mRNA in gonadal tissues of male mice. Sato M, et al. Biochem Biophys Res Commun, 1995 Oct 4. PMID 7575621
  4. Multiple copies of the bone-specific osteocalcin gene in mouse and rat. Rahman S, et al. Endocrinology, 1993 Dec. PMID 8243336
  5. Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice. Xu Z, et al. Front Physiol, 2023. PMID 37057181, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC123552

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydroxyapatite binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of bone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of bone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to vitamin K IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
osteocalcin-related protein
Names
bone gamma-carboxyglutamate protein, related sequence 1
gamma-carboxyglutamic acid-containing protein 3
nephrocalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305448.1 → NP_001292377.1  osteocalcin-related protein precursor

    See identical proteins and their annotated locations for NP_001292377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AA980874, AC102388, BY414395, BY430398
    Consensus CDS
    CCDS17472.1
    UniProtKB/Swiss-Prot
    P54615, Q78H72
    Related
    ENSMUSP00000103167.2, ENSMUST00000107543.8
    Conserved Domains (1) summary
    smart00069
    Location:31 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  2. NM_001305449.1 → NP_001292378.1  osteocalcin-related protein precursor

    See identical proteins and their annotated locations for NP_001292378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AA980874, AC102388, BY414395, BY430398
    Consensus CDS
    CCDS17472.1
    UniProtKB/Swiss-Prot
    P54615, Q78H72
    Conserved Domains (1) summary
    smart00069
    Location:31 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  3. NM_001305450.1 → NP_001292379.1  osteocalcin-related protein precursor

    See identical proteins and their annotated locations for NP_001292379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AA980874, AC102388, BY414395, BY430398
    Consensus CDS
    CCDS17472.1
    UniProtKB/Swiss-Prot
    P54615, Q78H72
    Conserved Domains (1) summary
    smart00069
    Location:31 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  4. NM_031368.5 → NP_112736.3  osteocalcin-related protein precursor

    See identical proteins and their annotated locations for NP_112736.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AA016947, AA475384, AC102388, BY414395, BY430398
    Consensus CDS
    CCDS17472.1
    UniProtKB/Swiss-Prot
    P54615, Q78H72
    Related
    ENSMUSP00000074965.5, ENSMUST00000075523.11
    Conserved Domains (1) summary
    smart00069
    Location:31 → 91
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88275923..88280048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54615.1 GenPept UniProtKB/Swiss-Prot:P54615

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