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MLH3 mutL homolog 3 [ Rana temporaria (common frog) ]

Gene ID: 120920631, updated on 21-Mar-2024

Summary

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Gene symbol
MLH3
Gene description
mutL homolog 3
See related
EnsemblRapid:ENSRTEG00010006817
Gene type
protein coding
RefSeq status
MODEL
Organism
Rana temporaria
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana; Rana
Orthologs
human mouse all
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Genomic context

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See MLH3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
13
Annotation release Status Assembly Chr Location
100 current aRanTem1.1 (GCF_905171775.1) 13 NC_053501.1 (15184635..15206331, complement)

Chromosome 13 - NC_053501.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase like 1 Neighboring gene protein RNA-directed DNA methylation 3-like Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene acylphosphatase 1 Neighboring gene NIMA related kinase 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_053501.1 Chromosome 13 Reference aRanTem1.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of mismatch repair complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA mismatch repair protein Mlh3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rana temporaria Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference aRanTem1.1

Genomic

  1. NC_053501.1 Reference aRanTem1.1

    Range
    15184635..15206331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040332813.1 → XP_040188747.1  DNA mismatch repair protein Mlh3 isoform X1

    Related
    ENSRTEP00010007738.1, ENSRTET00010011047.1
    Conserved Domains (3) summary
    smart00853
    Location:930 → 1106
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
    cl00075
    Location:12 → 192
    HATPase; Histidine kinase-like ATPase domain

  2. XM_040332815.1 → XP_040188749.1  DNA mismatch repair protein Mlh3 isoform X2

    Related
    ENSRTEP00010007741.1, ENSRTET00010011050.1
    Conserved Domains (3) summary
    smart00853
    Location:899 → 1075
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
    cl00075
    Location:12 → 192
    HATPase; Histidine kinase-like ATPase domain
Nucleotide Protein
Heading Accession and Version

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