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Bex3 brain expressed X-linked 3 [ Mus musculus (house mouse) ]

Gene ID: 12070, updated on 2-Nov-2024

Summary

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Official Symbol
Bex3provided by MGI
Official Full Name
brain expressed X-linked 3provided by MGI
Primary source
MGI:MGI:1338016
See related
Ensembl:ENSMUSG00000046432 AllianceGenome:MGI:1338016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nade; Gcap27; Ngfrap1; DXWsu67e
Summary
Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; liver; nervous system; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 289.2), CNS E18 (RPKM 196.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Bex3 in Genome Data Viewer
Location:
X F1; X 57.64 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135171002..135172727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136270253..136271978)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39535 Neighboring gene transcription elongation factor A like 9 Neighboring gene nuclear encoded rRNA 5S 12 Neighboring gene STARR-seq mESC enhancer starr_47977 Neighboring gene NSA2 ribosome biogenesis homolog, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Kim AJ, et al. Gene, 2004 Dec 8. PMID 15563833
  2. Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Brown AL, et al. Hum Mol Genet, 1999 Apr. PMID 10072429
  3. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. Calvo L, et al. J Neurosci, 2015 May 6. PMID 25948268, Free PMC Article
  4. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Yoon K, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178455
  5. Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis. Kendall SE, et al. Brain Res Dev Brain Res, 2003 Sep 10. PMID 12935912

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.
    Title: Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.
  2. NADE mRNA level remained invariant across development.
    Title: Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis.
  3. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis
    Title: Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.
  4. In situ hybridization demonstrates cellular co-localization of olfactory marker protein mRNA with mRNAs for Bex1, Bex2, and Bex3 in olfactory receptor neuronss in olfactory tissue of the mouse
    Title: Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables death receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nerve growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables nerve growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein BEX3
Names
brain-expressed X-linked protein 3 homolog
granule cell antiserum positive 27
nerve growth factor receptor (TNFRSF16) associated protein 1
nerve growth factor receptor-associated protein 1
p75NTR-associated Cell Death Executor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110233.1 → NP_001103703.1  protein BEX3 isoform a

    See identical proteins and their annotated locations for NP_001103703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AA681927, AV574205, AV575702, CD774851, CF618290
    Consensus CDS
    CCDS30419.1
    UniProtKB/Swiss-Prot
    A3KGA0, A3KGA1, Q9CWN9, Q9D0S2, Q9D1N5, Q9WTZ9
    Related
    ENSMUSP00000136952.2, ENSMUST00000178632.8
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 120
    BEX; Brain expressed X-linked like family

  2. NM_001110234.1 → NP_001103704.1  protein BEX3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AA681927, AV575702, CB055608, CD774851
    Consensus CDS
    CCDS53194.1
    UniProtKB/Swiss-Prot
    Q9WTZ9
    Related
    ENSMUSP00000108737.2, ENSMUST00000113112.2
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 110
    BEX; Brain expressed X-linked like family

  3. NM_009750.2 → NP_033880.1  protein BEX3 isoform a

    See identical proteins and their annotated locations for NP_033880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AA681927, AV575702, CD774851, CF618290
    Consensus CDS
    CCDS30419.1
    UniProtKB/Swiss-Prot
    A3KGA0, A3KGA1, Q9CWN9, Q9D0S2, Q9D1N5, Q9WTZ9
    Related
    ENSMUSP00000063039.5, ENSMUST00000053540.11
    Conserved Domains (1) summary
    pfam04538
    Location:1 → 120
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    135171002..135172727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTZ9.1 GenPept UniProtKB/Swiss-Prot:Q9WTZ9

Gene LinkOut

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