Bcl3 B cell leukemia/lymphoma 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl3provided by MGI
Official Full Name: B cell leukemia/lymphoma 3provided by MGI
Primary source: MGI:MGI:88140
See related: Ensembl:ENSMUSG00000053175 AllianceGenome:MGI:88140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bcl-3
Summary: Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to other organism; lymphocyte activation involved in immune response; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum adult (RPKM 114.5), small intestine adult (RPKM 82.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.95 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19542387..19556691, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19808462..19822824, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
Title: Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
IkB Protein BCL3 as a Controller of Osteogenesis and Bone Health.
Title: IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.
B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3.
Title: B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3.
NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii.
Title: NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii.
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1.
Title: Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1.
Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology.
Title: Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology.
Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
Title: Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
Bcl-3 suppresses differentiation of RORgammat(+) regulatory T cells.
Title: Bcl-3 suppresses differentiation of RORγt(+) regulatory T cells.
Bcl-3 inhibits lupus-like phenotypes in BL6/lpr mice.
Title: Bcl-3 inhibits lupus-like phenotypes in BL6/lpr mice.
The IkappaB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.
Title: The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3)
Endonuclease-mediated (4)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF067774 (e-PCR)
- UniSTS:163410

RH142265 (e-PCR)
- UniSTS:231512

PMC164513P1 (e-PCR)
- UniSTS:271487

PMC114562P3 (e-PCR)
- UniSTS:270271

BE447092 (e-PCR)
- UniSTS:208089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T-helper 1 type immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T-helper 2 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within follicular dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in response to UV-C	IEA Inferred from Electronic Annotation more info
involved_in response to UV-C	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Bcl3-Bcl10 complex	IEA Inferred from Electronic Annotation more info
part_of Bcl3-Bcl10 complex	ISO Inferred from Sequence Orthology more info
part_of Bcl3/NF-kappaB2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Bcl3/NF-kappaB2 complex	IEA Inferred from Electronic Annotation more info
part_of Bcl3/NF-kappaB2 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell lymphoma 3 protein homolog

Names: B-cell CLL/lymphoma 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033601.3 → NP_291079.2 B-cell lymphoma 3 protein homolog

See identical proteins and their annotated locations for NP_291079.2

Status: VALIDATED

Source sequence(s)

AF067774, AI528691, BY749796

Consensus CDS

CCDS20914.2

UniProtKB/Swiss-Prot

Q9Z2F6

UniProtKB/TrEMBL

Q3U300

Related

ENSMUSP00000113851.2, ENSMUST00000120537.8

Conserved Domains (3) summary

COG0666
Location:115 → 222

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:236 → 267

ANK; ANK repeat [structural motif]

pfam12796
Location:171 → 267

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19542387..19556691 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539487.5 → XP_006539550.1 B-cell lymphoma 3 protein homolog isoform X1

UniProtKB/TrEMBL

Q3U300

Conserved Domains (3) summary

COG0666
Location:115 → 222

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:236 → 267

ANK; ANK repeat [structural motif]

pfam12796
Location:171 → 267

Ank_2; Ankyrin repeats (3 copies)