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INSR insulin receptor [ Mauremys reevesii (Reeves's turtle) ]

Gene ID: 120391598, updated on 11-Apr-2024

Summary

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Gene symbol
INSR
Gene description
insulin receptor
Gene type
protein coding
RefSeq status
MODEL
Organism
Mauremys reevesii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Testudinoidea; Geoemydidae; Geoemydinae; Mauremys
Orthologs
human mouse all
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Genomic context

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See INSR in Genome Data Viewer
Location:
chromosome: 26
Exon count:
26
Annotation release Status Assembly LG Location
100 current ASM1616193v1 (GCF_016161935.1) 26 NC_052648.1 (811037..922439)

Linkage Group 26 - NC_052648.1Genomic Context describing neighboring genes Neighboring gene myosin IXB Neighboring gene unconventional SNARE in the ER 1 Neighboring gene rho guanine nucleotide exchange factor 18-like Neighboring gene Rho/Rac guanine nucleotide exchange factor 18

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_052648.1 Chromosome 26 Reference ASM1616193v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mauremys reevesii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1616193v1 Primary Assembly

Genomic

  1. NC_052648.1 Reference ASM1616193v1 Primary Assembly

    Range
    811037..922439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039515409.1 → XP_039371343.1  insulin receptor isoform X1

    Conserved Domains (5) summary
    cd05061
    Location:987 → 1274
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:838 → 921
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:172 → 327
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:348 → 459
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:917 → 963
    Insulin_TMD; Insulin receptor trans-membrane segment

  2. XM_039515415.1 → XP_039371349.1  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:143 → 298
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:319 → 430
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:888 → 934
    Insulin_TMD; Insulin receptor trans-membrane segment

  3. XM_039515416.1 → XP_039371350.1  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:143 → 298
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:319 → 430
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:888 → 934
    Insulin_TMD; Insulin receptor trans-membrane segment

  4. XM_039515412.1 → XP_039371346.1  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:143 → 298
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:319 → 430
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:888 → 934
    Insulin_TMD; Insulin receptor trans-membrane segment

  5. XM_039515410.1 → XP_039371344.1  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:143 → 298
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:319 → 430
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:888 → 934
    Insulin_TMD; Insulin receptor trans-membrane segment

  6. XM_039515411.1 → XP_039371345.1  insulin receptor isoform X2

    Conserved Domains (5) summary
    cd05061
    Location:958 → 1245
    PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
    cd00063
    Location:809 → 892
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:143 → 298
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:319 → 430
    Recep_L_domain; Receptor L domain
    pfam17870
    Location:888 → 934
    Insulin_TMD; Insulin receptor trans-membrane segment
Nucleotide Protein
Heading Accession and Version

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