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HSPG2 heparan sulfate proteoglycan 2 [ Crotalus tigris (Tiger rattlesnake) ]

Gene ID: 120319186, updated on 21-Mar-2024

Summary

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Gene symbol
HSPG2
Gene description
heparan sulfate proteoglycan 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Crotalus tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus
Orthologs
human mouse all
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Genomic context

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See HSPG2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
105
Annotation release Status Assembly Chr Location
100 current ASM1654583v1 (GCF_016545835.1) Unplaced Scaffold NW_024098092.1 (194142..304263)

NW_024098092.1Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase 2 Neighboring gene tripartite motif containing 62 Neighboring gene transmembrane protein 269 Neighboring gene chymotrypsin-like elastase family member 3B Neighboring gene small vasohibin binding protein Neighboring gene proproteinase E-like Neighboring gene ubiquitin specific peptidase 48 Neighboring gene RAP1 GTPase activating protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_024098092 Unplaced Scaffold Reference ASM1654583v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Crotalus tigris Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1654583v1

Genomic

  1. NW_024098092.1 Reference ASM1654583v1

    Range
    194142..304263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039367735.1 → XP_039223669.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X8

    Conserved Domains (17) summary
    cd05743
    Location:456 → 533
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3439 → 3516
    IG; Immunoglobulin
    smart00410
    Location:3706 → 3783
    IG_like; Immunoglobulin like
    cd00054
    Location:3964 → 3997
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1202 → 1251
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4046 → 4199
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:360 → 394
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4224 → 4255
    EGF; EGF-like domain
    pfam00052
    Location:1034 → 1168
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1314 → 1361
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:401 → 438
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3617 → 3696
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3347 → 3416
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3715 → 3724
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2079 → 2164
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:70 → 181
    SEA; SEA domain
    cl11960
    Location:3523 → 3600
    Ig; Immunoglobulin domain

  2. XM_039367729.1 → XP_039223663.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3496 → 3573
    IG; Immunoglobulin
    smart00410
    Location:3763 → 3840
    IG_like; Immunoglobulin like
    cd00054
    Location:4021 → 4054
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4103 → 4256
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4281 → 4312
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3674 → 3753
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3404 → 3473
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3772 → 3781
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2136 → 2221
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3580 → 3657
    Ig; Immunoglobulin domain

  3. XM_039367731.1 → XP_039223665.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X4

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3099 → 3175
    IG; Immunoglobulin
    smart00410
    Location:3736 → 3813
    IG_like; Immunoglobulin like
    cd00054
    Location:3994 → 4027
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4076 → 4229
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4254 → 4285
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3647 → 3726
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2340 → 2412
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3745 → 3754
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2136 → 2221
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3553 → 3630
    Ig; Immunoglobulin domain

  4. XM_039367730.1 → XP_039223664.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3476 → 3553
    IG; Immunoglobulin
    smart00410
    Location:3743 → 3820
    IG_like; Immunoglobulin like
    cd00054
    Location:4001 → 4034
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4083 → 4236
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4261 → 4292
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3654 → 3733
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3384 → 3453
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3752 → 3761
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2136 → 2221
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3560 → 3637
    Ig; Immunoglobulin domain

  5. XM_039367736.1 → XP_039223670.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X9

    Conserved Domains (18) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:2658 → 2734
    IG; Immunoglobulin
    smart00410
    Location:3675 → 3752
    IG_like; Immunoglobulin like
    PHA03378
    Location:1531 → 1631
    PHA03378; EBNA-3B; Provisional
    cd00054
    Location:3933 → 3966
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4015 → 4168
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4193 → 4224
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3586 → 3665
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3316 → 3385
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3684 → 3693
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2048 → 2133
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3492 → 3569
    Ig; Immunoglobulin domain

  6. XM_039367737.1 → XP_039223671.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X10

    Conserved Domains (18) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3377 → 3454
    IG; Immunoglobulin
    smart00410
    Location:3644 → 3721
    IG_like; Immunoglobulin like
    cd00054
    Location:3902 → 3935
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3984 → 4137
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4162 → 4193
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3555 → 3634
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3285 → 3354
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3653 → 3662
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2017 → 2102
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3461 → 3538
    Ig; Immunoglobulin domain
    cl28929
    Location:1517 → 1687
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  7. XM_039367732.1 → XP_039223666.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X5

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3462 → 3539
    IG; Immunoglobulin
    smart00410
    Location:3729 → 3806
    IG_like; Immunoglobulin like
    cd00054
    Location:3987 → 4020
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4069 → 4222
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4247 → 4278
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3640 → 3719
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3370 → 3439
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3738 → 3747
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2102 → 2187
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3546 → 3623
    Ig; Immunoglobulin domain

  8. XM_039367738.1 → XP_039223672.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X11

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3229 → 3306
    IG; Immunoglobulin
    smart00410
    Location:3496 → 3573
    IG_like; Immunoglobulin like
    cd00054
    Location:3754 → 3787
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3836 → 3989
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4014 → 4045
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3407 → 3486
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3137 → 3206
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3505 → 3514
    Ig; Ig strand B [structural motif]
    cd05754
    Location:1869 → 1954
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3313 → 3390
    Ig; Immunoglobulin domain

  9. XM_039367734.1 → XP_039223668.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X7

    Conserved Domains (17) summary
    cd05743
    Location:473 → 550
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3723 → 3800
    IG; Immunoglobulin
    smart00410
    Location:3273 → 3354
    IG_like; Immunoglobulin like
    cd00054
    Location:3981 → 4014
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1219 → 1268
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4063 → 4216
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:377 → 411
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4241 → 4272
    EGF; EGF-like domain
    pfam00052
    Location:1051 → 1185
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1331 → 1378
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:418 → 455
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3634 → 3713
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3364 → 3433
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3647 → 3651
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2096 → 2181
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3540 → 3617
    Ig; Immunoglobulin domain

  10. XM_039367728.1 → XP_039223662.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

    Conserved Domains (17) summary
    cd05743
    Location:500 → 577
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3750 → 3827
    IG; Immunoglobulin
    smart00410
    Location:3483 → 3560
    IG_like; Immunoglobulin like
    cd00054
    Location:4008 → 4041
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1246 → 1295
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4090 → 4243
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:404 → 438
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4268 → 4299
    EGF; EGF-like domain
    pfam00052
    Location:1078 → 1212
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1358 → 1405
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:445 → 482
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3661 → 3740
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3391 → 3460
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3674 → 3678
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2123 → 2208
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 237
    SEA; SEA domain
    cl11960
    Location:3567 → 3644
    Ig; Immunoglobulin domain

  11. XM_039367733.1 → XP_039223667.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X6

    Conserved Domains (17) summary
    cd05743
    Location:476 → 553
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3089 → 3165
    IG; Immunoglobulin
    smart00410
    Location:3726 → 3803
    IG_like; Immunoglobulin like
    cd00054
    Location:3984 → 4017
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1222 → 1271
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4066 → 4219
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:380 → 414
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4244 → 4275
    EGF; EGF-like domain
    pfam00052
    Location:1054 → 1188
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1334 → 1381
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:421 → 458
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3637 → 3716
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3367 → 3436
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3735 → 3744
    Ig; Ig strand B [structural motif]
    cd05754
    Location:2099 → 2184
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:88 → 201
    SEA; SEA domain
    cl11960
    Location:3543 → 3620
    Ig; Immunoglobulin domain

  12. XM_039367739.1 → XP_039223673.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X12

    Conserved Domains (17) summary
    cd05743
    Location:513 → 590
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3449 → 3526
    IG; Immunoglobulin
    smart00410
    Location:3182 → 3259
    IG_like; Immunoglobulin like
    cd00054
    Location:3707 → 3740
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1259 → 1308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3789 → 3942
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:417 → 451
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:3967 → 3998
    EGF; EGF-like domain
    pfam00052
    Location:1091 → 1225
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1371 → 1418
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:458 → 495
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3360 → 3439
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2053 → 2125
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3373 → 3377
    Ig; Ig strand B [structural motif]
    cd05754
    Location:1869 → 1954
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 238
    SEA; SEA domain
    cl11960
    Location:3266 → 3343
    Ig; Immunoglobulin domain

  13. XM_039367741.1 → XP_039223675.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X13

    Conserved Domains (17) summary
    cd05743
    Location:500 → 577
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3456 → 3533
    IG; Immunoglobulin
    smart00410
    Location:3189 → 3266
    IG_like; Immunoglobulin like
    cd00054
    Location:3714 → 3747
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1246 → 1295
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3796 → 3949
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:404 → 438
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:3974 → 4005
    EGF; EGF-like domain
    pfam00052
    Location:1078 → 1212
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1358 → 1405
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:445 → 482
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3367 → 3446
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2060 → 2132
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3380 → 3384
    Ig; Ig strand B [structural motif]
    cd05754
    Location:1856 → 1941
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 237
    SEA; SEA domain
    cl11960
    Location:3273 → 3350
    Ig; Immunoglobulin domain

  14. XM_039367742.1 → XP_039223676.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X14

    Conserved Domains (17) summary
    cd05743
    Location:500 → 577
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00409
    Location:3436 → 3513
    IG; Immunoglobulin
    smart00410
    Location:3169 → 3246
    IG_like; Immunoglobulin like
    cd00054
    Location:3694 → 3727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1246 → 1295
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3776 → 3929
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:404 → 438
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:3954 → 3985
    EGF; EGF-like domain
    pfam00052
    Location:1078 → 1212
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1358 → 1405
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:445 → 482
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3347 → 3426
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2040 → 2112
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3360 → 3364
    Ig; Ig strand B [structural motif]
    cd05754
    Location:1856 → 1941
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl02507
    Location:127 → 237
    SEA; SEA domain
    cl11960
    Location:3253 → 3330
    Ig; Immunoglobulin domain
Nucleotide Protein
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