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ACTN2 actinin alpha 2 [ Crotalus tigris (Tiger rattlesnake) ]

Gene ID: 120318759, updated on 21-Mar-2024

Summary

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Gene symbol
ACTN2
Gene description
actinin alpha 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Crotalus tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus
Orthologs
human mouse all
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Genomic context

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See ACTN2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
100 current ASM1654583v1 (GCF_016545835.1) Unplaced Scaffold NW_024097997.1 (117040..189104, complement)

NW_024097997.1Genomic Context describing neighboring genes Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase Neighboring gene uncharacterized LOC120318760 Neighboring gene HEAT repeat-containing protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_024097997 Unplaced Scaffold Reference ASM1654583v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Crotalus tigris Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1654583v1

Genomic

  1. NW_024097997.1 Reference ASM1654583v1

    Range
    117040..189104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039366808.1 → XP_039222742.1  alpha-actinin-2

    Conserved Domains (6) summary
    cd00051
    Location:758 → 820
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:406 → 630
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:282 → 392
    Spectrin; Spectrin repeat
    pfam08726
    Location:825 → 891
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:36 → 140
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:144 → 258
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
Nucleotide Protein
Heading Accession and Version

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