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DRD4 dopamine receptor D4 [ Canis lupus familiaris (dog) ]

Gene ID: 119864199, updated on 17-Aug-2024

Summary

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Official Symbol
DRD4provided by VGNC
Official Full Name
dopamine receptor D4provided by VGNC
Primary source
VGNC:VGNC:110590
See related
Ensembl:ENSCAFG00845017368
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See DRD4 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (26314100..26316803)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (25378476..25381179)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (26081003..26083706)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (25823586..25826358)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (25468566..25471386)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene cadherin related family member 5 Neighboring gene secretin Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs. Wan M, et al. Anim Genet, 2013 Dec. PMID 23713429
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
    Title: DRD4 and TH gene polymorphisms are associated with activity, impulsivity and inattention in Siberian Husky dogs.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
D(4) dopamine receptor; LOW QUALITY PROTEIN: D(4) dopamine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    26314100..26316803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424041.1 → XP_038279969.1  D(4) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    Q589Y6
    Related
    ENSCAFP00845024128.1, ENSCAFT00845030767.1
    Conserved Domains (2) summary
    cd14964
    Location:63 → 89
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:39 → 423
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    25823586..25826358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500400.1 → XP_038356328.1  LOW QUALITY PROTEIN: D(4) dopamine receptor isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    25468566..25471386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627083.1 → XP_038483011.1  LOW QUALITY PROTEIN: D(4) dopamine receptor isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    26081003..26083706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562962.1 → XP_038418890.1  D(4) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    Q589Y6
    Conserved Domains (2) summary
    cd14964
    Location:63 → 89
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:39 → 423
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25378476..25381179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454403.1 → XP_038310331.1  D(4) dopamine receptor isoform X1

    UniProtKB/TrEMBL
    Q589Y6
    Conserved Domains (2) summary
    cd14964
    Location:63 → 89
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:39 → 423
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
Heading Accession and Version

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