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Tjp2 tight junction protein 2 [ Arvicola amphibius (Eurasian water vole) ]

Gene ID: 119823437, updated on 21-Mar-2024

Summary

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Gene symbol
Tjp2
Gene description
tight junction protein 2
See related
EnsemblRapid:ENSAAPG00005002511
Gene type
protein coding
RefSeq status
MODEL
Organism
Arvicola amphibius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Arvicolinae; Arvicola
Orthologs
human mouse all
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Genomic context

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See Tjp2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
25
Annotation release Status Assembly Chr Location
101 current mArvAmp1.2 (GCF_903992535.2) 1 NC_052047.1 (165386912..165502927, complement)
100 previous assembly mArvAmp1.1 (GCF_903992535.1) 1 NC_052047.1 (165386912..165502927, complement)

Chromosome 1 - NC_052047.1Genomic Context describing neighboring genes Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene uncharacterized LOC119806745 Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Arvicola amphibius Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mArvAmp1.2

Genomic

  1. NC_052047.1 Reference mArvAmp1.2

    Range
    165386912..165502927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038343471.1 → XP_038199399.1  tight junction protein ZO-2 isoform X2

    Related
    ENSAAPP00005003195.1, ENSAAPT00005003507.2
    Conserved Domains (4) summary
    cd12027
    Location:582 → 644
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:678 → 857
    GuKc; Guanylate kinase homologues
    smart00228
    Location:286 → 363
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. XM_038343463.1 → XP_038199391.1  tight junction protein ZO-2 isoform X2

    Conserved Domains (4) summary
    cd12027
    Location:582 → 644
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:678 → 857
    GuKc; Guanylate kinase homologues
    smart00228
    Location:286 → 363
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_038343477.1 → XP_038199405.1  tight junction protein ZO-2 isoform X3

    Conserved Domains (4) summary
    cd12027
    Location:605 → 667
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:701 → 880
    GuKc; Guanylate kinase homologues
    smart00228
    Location:309 → 386
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. XM_038343455.1 → XP_038199383.1  tight junction protein ZO-2 isoform X1

    Related
    ENSAAPP00005003261.1, ENSAAPT00005003578.2
    Conserved Domains (4) summary
    cd12027
    Location:605 → 667
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:701 → 880
    GuKc; Guanylate kinase homologues
    smart00228
    Location:309 → 386
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
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