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BB_RS03030 integrin-binding adhesin P66 [ Borreliella burgdorferi B31 ]

Gene ID: 1195450, discontinued on 22-Mar-2020
  • This record was discontinued.

Summary

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Gene symbol
BB_RS03030
Gene description
integrin-binding adhesin P66
Locus tag
BB_RS03030
Gene type
protein coding
RefSeq status
PIPELINE
Organism
Borreliella burgdorferi B31 (strain: B31, type-material: type strain of Borreliella burgdorferi)
Lineage
Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella
Old locus tag
BB_0603
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001318.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HtrA degraded p66 in vitro and the A3HtrAOE strain expressed reduced levels of p66 in vivo.
    Title: Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66.
  2. P66 is the first integrin-binding protein to have a documented and direct role in vascular transmigration
    Title: Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein.
  3. Either mutation of two amino acids (D205A,D207A), or deletion of seven amino acids (Del202-208) of the Borrelia burgdorferi P66 protein significantly reduced binding ability to integrin alphavbeta3.
    Title: Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity.
  4. P66 is an octamer with a molecular mass of approximately 460 kDa.
    Title: Use of nonelectrolytes reveals the channel size and oligomeric constitution of the Borrelia burgdorferi P66 porin.
  5. Authors provide evidence that the borrelial outer membrane protein P66, a known adhesin with pore-forming activity, forms a beta-barrel in the Borrelia burgdorferi outer membrane.
    Title: Structural modeling and physicochemical characterization provide evidence that P66 forms a β-barrel in the Borrelia burgdorferi outer membrane.
  6. This study is the first to define a Borrelia burgdorferi P66 adhesin as essential for mammalian, but not tick infection.
    Title: The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks.
  7. This study demonistrated that Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.
    Title: Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.
  8. Changes in the expression of p66 and bb0232 in the tick at various points with respect to feeding on mice are consistent with Hbb/BB0232 being involved in regulating p66 expression
    Title: Interaction of Borrelia burgdorferi Hbb with the p66 promoter.
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General protein information

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Preferred Names
integrin-binding adhesin P66

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001318.1 Reference assembly

    Range
    627092..628948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_002656762.1 integrin-binding adhesin P66 [Borreliella burgdorferi]

    See identical proteins and their annotated locations for WP_002656762.1

    Status: PIPELINE

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials