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lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [ Aquifex aeolicus VF5 ]

Gene ID: 1193363, discontinued on 6-Mar-2020
  • This record was discontinued.

Summary

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Gene symbol
lpxC
Gene description
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Locus tag
aq_1772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Aquifex aeolicus VF5 (strain: VF5)
Lineage
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex
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Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000918.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The X-ray crystal structure of the LpxC-uridine 5'-diphosphate (UDP) complex provides the first view of interactions likely to be exploited by the substrate UDP group in the "basic patch" of the active site.
    Title: Binding of uridine 5'-diphosphate in the "basic patch" of the zinc deacetylase LpxC and implications for substrate binding.
  2. LpxC catalyzes deacetylation by using Glu78 and His265 as a general acid-base pair and the zinc-bound water as a nucleophile
    Title: UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
Submit: New GeneRIF Correction

General protein information

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Names
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
NP_214214.1
  • zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000918.1 Reference assembly

    Range
    1250094..1250942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214214.1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [Aquifex aeolicus VF5]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O67648.1

Gene LinkOut

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Molecular Biology Databases